Bomyntra Dosage

Important Administration Instructions

Bomyntra should be administered by a healthcare provider.

Bomyntra is intended for subcutaneous route only and should not be administered intravenously, intramuscularly, or intradermally.

Multiple Myeloma and Bone Metastasis from Solid Tumors

The recommended dose of Bomyntra is 120 mg administered as a subcutaneous injection every 4 weeks in the upper arm, upper thigh, or abdomen.

Administer calcium and vitamin D as necessary to treat or prevent hypocalcemia.

Giant Cell Tumor of Bone

The recommended dose of Bomyntra is 120 mg administered every 4 weeks with additional 120 mg doses on Days 8 and 15 of the first month of therapy. Administer subcutaneously in the upper arm, upper thigh, or abdomen.

Administer calcium and vitamin D as necessary to treat or prevent hypocalcemia.

Hypercalcemia of Malignancy

The recommended dose of Bomyntra is 120 mg administered every 4 weeks with additional 120 mg doses on Days 8 and 15 of the first month of therapy. Administer subcutaneously in the upper arm, upper thigh, or abdomen.

Preparation and Administration

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Bomyntra is a clear, colorless to pale yellow solution that is free from visible particles. Do not use if the solution is discolored or cloudy or if the solution contains particles or foreign particulate matter.

Prior to administration, Bomyntra may be removed from the refrigerator and brought to room temperature (up to 25°C/77°F) by standing in the original container. This generally takes 15 to 30 minutes. Do not warm Bomyntra in any other way.

Instructions for Administration of Bomyntra Prefilled Syringe with Needle Safety Guard

IMPORTANT:

In order to minimize accidental needlesticks, the Bomyntra single-dose prefilled syringe has an automatic clear needle safety guard.

Bomyntra prefilled syringe (Before & After use). See figure below.

Step 1: Remove Needle Cap (see Figure A) Do not hold the prefilled syringe by the plunger rod. Do not twist or bend the needle cap.	Figure A
Step 2: Administer Subcutaneous Injection Choose an injection site. The recommended injection sites for Bomyntra include (see Figure B):
upper thigh abdomen upper arm Do not administer into muscle or blood vessel. Pinch the skin and insert the needle at a 45 to 90-degree angle. Push the plunger with a slow and constant pressure until you cannot press further and have injected all the liquid subcutaneously (see Figure C). You may hear or feel a “click”.	Figure B Figure C
Step 3. Release Plunger Keeping the prefilled syringe at the injection site, slowly release the plunger and lift syringe off the skin. The clear needle guard will automatically cover the needle (see Figure D).
Do not recap the needle. Immediately dispose of used prefilled syringe into a sharps disposal container.	Figure D