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Aloprim Dosage

Generic name: ALLOPURINOL SODIUM 500mg in 25mL
Dosage form: injection, powder, lyophilized, for solution
Drug classes: Antigout agents, Antihyperuricemic agents

Medically reviewed by Last updated on Jan 29, 2024.

Recommended Dosage

Initiate therapy with ALOPRIM 24 to 48 hours before the start of chemotherapy known to cause tumor cell lysis. Additionally, administer fluids sufficient to yield a daily urinary output of at least two liters in adults with a neutral or, preferably, slightly alkaline urine.

The recommended daily dose of ALOPRIM is shown in Table 1. Administer the daily dose as single infusion or in equally divided infusions at 6-, 8-, or 12-hour intervals at a rate appropriate for the volume of infusate.

Table 1: Recommended Daily Dose of ALOPRIM

Adult Patients

200 mg/m2/day to 400 mg/m2/day intravenously
Maximum 600 mg/day

Pediatric Patients

Starting Dose 200 mg/m2/day intravenously

Maximum 400 mg/day

The dosage of ALOPRIM to lower serum uric acid to normal or near-normal varies with the severity of the disease. Monitor serum uric acid levels at least daily and administer ALOPRIM at a dose and frequency to maintain the serum uric acid within the normal range. Discontinue ALOPRIM when the patient is able to take oral therapy or when the risk of tumor lysis has abated.

Dosage Modifications in Patients with Renal Impairment

Reduce the dose of ALOPRIM in patients with impaired renal function [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. The recommended dosage reductions of ALOPRIM in adult patients with renal impairment are shown in Table 2.

Table 2: Recommended Daily Dose of ALOPRIM in Adult Patients with Renal Impairment
Creatinine Clearance Recommended Daily Dose

10 to 20 mL/min

200 mg/day

Less than 10 mL/min

100 mg/day

On dialysis

50 mg every 12 hours, or

100 mg every 24 hours

Treatment with ALOPRIM has not been studied in pediatric patients with severe renal impairment or on dialysis. For pediatric patients with severe renal impairment or on dialysis, consider the risks and potential benefits before initiating treatment with ALOPRIM [see Warnings and Precautions (5.2) and Use In Specific Populations (8.6)].

Preparation Instructions

Reconstitue and further dilute ALOPRIM prior to intravenous infusion.


Reconstitute each vial of ALOPRIM with 25 mL of Sterile Water for Injection, USP to obtain a concentration of 20 mg/mL of allopurinol.
Inspect the reconstituted solution for discoloration and particulate matter. The reconstituted solution should appear as a clear, almost colorless solution with no more than a slight opalescence. Do not use if the reconstituted solution contains particulate matter or discoloration is present.


Dilute with 0.9% Sodium Chloride Injection, USP or 5% Dextrose for Injection, USP to obtain a final concentration of less than 6 mg/mL.
Inspect the diluted solution for particulate matter or discoloration and discard if present.
If not used immediately, the diluted ALOPRIM solution can be stored at 20° to 25°C (68° to 77°F) for up to 10 hours after initial reconstitution. The storage includes time for infusion. Do not refrigerate the reconstituted and/or diluted product.
If stored, the administration should be completed within 10 hours after reconstitution.
Discard unused portion.

Administration Instructions

Do not mix ALOPRIM with or administer it through the same intravenous port as agents which are incompatible in solution with ALOPRIM. The following table lists drugs that are known to be physically incompatible in solution with ALOPRIM.

Table 3: Drugs That Are Physically Incompatible in Solution with ALOPRIM

Amikacin sulfate

Hydroxyzine HCl

Amphotericin B

Idarubicin HCl


Imipenem-cilastatin sodium

Cefotaxime sodium

Mechlorethamine HCl

Chlorpromazine HCl

Meperidine HCl

Cimetidine HCl

Metoclopramide HCl

Clindamycin phosphate

Methylprednisolone sodium succinate


Minocycline HCl


Nalbuphine HCl

Daunorubicin HCl

Ondansetron HCl

Diphenhydramine HCl

Prochlorperazine edisylate

Doxorubicin HCl

Promethazine HCl

Doxycycline hyclate

Sodium bicarbonate




Tobramycin sulfate

Gentamicin sulfate

Vinorelbine tartrate

Haloperidol lactate

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.