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Aloprim Dosage

Generic name: ALLOPURINOL SODIUM 500mg in 25mL
Dosage form: injection, powder, lyophilized, for solution

Children and Adults

The dosage of ALOPRIM (allopurinol) for Injection to lower serum uric acid to normal or near-normal varies with the severity of the disease. The amount and frequency of dosage for maintaining the serum uric acid just within the normal range is best determined by using the serum uric acid level as an index. In adults, in one clinical trial, doses over 600 mg a day did not appear to be more effective. The recommended daily dose of ALOPRIM (allopurinol) for Injection is as follows:

Recommended Daily Dose


200 to 400 mg/m2/day
Maximum 600 mg/day


Starting Dose 200 mg/m2/day


A fluid intake sufficient to yield a daily urinary output of at least two liters in adults and the maintenance of a neutral or, preferably, slightly alkaline urine are desirable.

Impaired Renal Function

The dose of ALOPRIM (allopurinol) for Injection should be reduced in patients with impaired renal function to avoid accumulation of allopurinol and its metabolites:

Creatinine Clearance Recommended Daily Dose

10 to 20 mL/min

200 mg/day

3 to 10 mL/min

100 mg/day

< 3 mL/min

100 mg/day at extended intervals


In both adults and children, the daily dose can be given as single infusion or in equally divided infusions at 6-, 8-, or 12-hour intervals at the recommended final concentration of not greater than 6 mg/mL (see Preparation of Solution). The rate of infusion depends on the volume of infusate. Whenever possible, therapy with ALOPRIM (allopurinol) for Injection should be initiated 24 to 48 hours before the start of chemotherapy known to cause tumor cell lysis (including adrenocorticosteroids).

ALOPRIM (allopurinol) for Injection should not be mixed with or administered through the same intravenous port with agents which are incompatible in solution with ALOPRIM (allopurinol) for Injection (see Preparation of Solution).

Preparation of Solution

ALOPRIM (allopurinol) for Injection must be reconstituted and diluted. The contents of each 30 mL vial should be dissolved with 25 mL of Sterile Water for Injection. The reconstituted solution contains allopurinol at a concentration of 20 mg/mL. Reconstitution yields a clear, almost colorless solution with no more than a slight opalescence. This concentrated solution has a pH of 11.1 to 11.8. It should be diluted to the desired concentration with 0.9% Sodium Chloride Injection or 5% Dextrose for Injection. Sodium bicarbonate-containing solutions should not be used. A final concentration of no greater than 6 mg/mL is recommended. The solution should be stored at 20° to 25°C (68° to 77°F) and administration should begin within 10 hours after reconstitution. Do not refrigerate the reconstituted and/or diluted product. Discard unused portion.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use this product if particulate matter or discoloration is present.

The following table lists drugs that are physically incompatible in solution with ALOPRIM (allopurinol) for Injection.

Drugs That Are Physically Incompatible in Solution with ALOPRIM® (allopurinol) for Injection

Amikacin sulfate

Hydroxyzine HCl

Amphotericin B

Idarubicin HCl


Imipenem-cilastatin sodium

Cefotaxime sodium

Mechlorethamine HCl

Chlorpromazine HCl

Meperidine HCl

Cimetidine HCl

Metoclopramide HCl

Clindamycin phosphate

Methylprednisolone sodium succinate


Minocycline HCl


Nalbuphine HCl

Daunorubicin HCl

Netilmicin sulfate

Diphenhydramine HCl

Ondansetron HCl

Doxorubicin HCl

Prochlorperazine edisylate

Doxycycline hyclate

Promethazine HCl


Sodium bicarbonate



Gentamicin sulfate

Tobramycin sulfate

Haloperidol lactate

Vinorelbine tartrate

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.