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Zaltrap (ziv-aflibercept) Disease Interactions

There is 1 disease interaction with Zaltrap (ziv-aflibercept):


Ziv-Aflibercept (Includes Zaltrap) ↔ Hemorrhage

Severe Potential Hazard, Moderate plausibility

Applies to: Gastrointestinal Perforation, Bleeding

Ziv-aflibercept can impair wound healing, cause gastrointestinal (GI) perforation, and cause severe and sometimes fatal hemorrhages including GI hemorrhage. It is recommended to suspend the use of ziv-aflibercept for at least 4 weeks prior to elective surgery and do not resume treatment for at least 4 weeks following major surgery and until the surgical wound is fully healed. Monitor patients for signs and symptoms of GI perforation. It is recommended to discontinue the use of this agent in patients who experience GI perforation or in patients with compromised wound healing.

Zaltrap (ziv-aflibercept) drug Interactions

There are 107 drug interactions with Zaltrap (ziv-aflibercept)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.