Zenocutuzumab Disease Interactions
There are 4 disease interactions with zenocutuzumab.
Zenocutuzumab (applies to zenocutuzumab) congestive heart failure
Moderate Potential Hazard, Moderate plausibility.
Zenocutuzumab can cause left ventricular dysfunction and has not been studied in patients with a history of clinically significant cardiac disease or left ventricular ejection fraction (LVEF) less than 50% prior to treatment initiation. LVEF should be evaluated prior to using this drug and monitored at regular intervals during treatment.
References (1)
- (2024) "Product Information. Bizengri (zenocutuzumab)." Merus US, Inc
Zenocutuzumab (applies to zenocutuzumab) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The pharmacokinetics of zenocutuzumab have not been studied in patients with moderate to severe hepatic impairment (total bilirubin greater than 1.5 to 3 times upper limit of normal with any AST).
References (1)
- (2024) "Product Information. Bizengri (zenocutuzumab)." Merus US, Inc
Zenocutuzumab (applies to zenocutuzumab) pulmonary impairment
Moderate Potential Hazard, Moderate plausibility.
Zenocutuzumab can cause interstitial lung disease (ILD) and pneumonitis. New or worsening pulmonary symptoms that can indicate ILD or pneumonitis such as dyspnea, cough, or fever, should be closely monitored.
References (1)
- (2024) "Product Information. Bizengri (zenocutuzumab)." Merus US, Inc
Zenocutuzumab (applies to zenocutuzumab) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
The pharmacokinetics of zenocutuzumab in patients with severe renal impairment (CrCl less than 30 mL/min) is unknown.
References (1)
- (2024) "Product Information. Bizengri (zenocutuzumab)." Merus US, Inc
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Zenocutuzumab drug interactions
There are 95 drug interactions with zenocutuzumab.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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