Tryptophan Disease Interactions
There are 3 disease interactions with tryptophan:
Anxiolytics/sedatives/hypnotics (Includes tryptophan) ↔ depression
Severe Potential Hazard, Moderate plausibility. Applies to: Depression
A variety of abnormal thinking and behavior changes have been reported to occur in association with the use of most anxiolytics, sedatives and hypnotics. Some of these changes include decreased inhibition, aggressiveness, agitation, and hallucinations. These drugs can cause or exacerbate mental depression and cause suicidal behavior and ideation. Therapy with these drugs should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. It may be prudent to refrain from dispensing large quantities of medication to these patients.
- "Product Information. Ambien (zolpidem)." sanofi-aventis, Bridgewater, NJ.
- "Product Information. Placidyl (ethchlorvynol)." Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Equanil (meprobamate)." Wallace Laboratories, Cranbury, NJ.
- "Product Information. Aquachloral Supprettes (chloral hydrate)." Medisca, Plattsburg, NY.
Anxiolytics/sedatives/hypnotics (Includes tryptophan) ↔ glaucoma
Moderate Potential Hazard, Moderate plausibility. Applies to: Glaucoma/Intraocular Hypertension, Urinary Retention
Some hypnotic drugs can have an anticholinergic effect and should be used with caution in patients with glaucoma, and trouble urinating due to retention or enlarged prostate.
Anxiolytics/sedatives/hypnotics (Includes tryptophan) ↔ liver disease
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
In general, anxiolytics, sedatives and hypnotics are extensively metabolized by the liver. Their plasma clearance may be decreased and their half-life prolonged in patients with impaired hepatic function. Therapy with these drugs should be administered cautiously in patients with liver disease (some are not recommended in severe liver impairment), and the dosage should be adjusted accordingly. Laboratory testing is recommended prior and during treatment.
Tryptophan drug interactions
There are 181 drug interactions with tryptophan
More about tryptophan
- Tryptophan Side Effects
- Drug Interactions
- Support Group
- En Español
- 8 Reviews
- Drug class: miscellaneous anxiolytics, sedatives and hypnotics
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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