Sodium zirconium cyclosilicate Disease Interactions

The use of sodium zirconium cyclosilicate should be avoided in patients with severe constipation, bowel obstruction or impaction, including abnormal postoperative bowel motility disorders. This medication has not been studied in patients with these conditions and may be ineffective and it may worsen gastrointestinal conditions.

Each 5 g dose of sodium zirconium cyclosilicate contains approximately 400 mg of sodium, and can cause edema, which was generally mild to moderate in severity in clinical trials. Patients should be monitored for signs of edema, particularly those who should restrict their sodium intake or are prone to fluid overload (e.g., heart failure or renal disease). Advise patients to adjust dietary sodium, and if appropriate, increase the dose of diuretics as needed.