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Phosphate Laxative Disease Interactions

There are 6 disease interactions with Phosphate Laxative (sodium biphosphate / sodium phosphate).

Major

Alkalinizing agents (applies to Phosphate Laxative) sodium/water balance

Major Potential Hazard, Moderate plausibility. Applicable conditions: Hypernatremia, Fluid Retention

Alkalinizing agents containing sodium can induce sodium and water retention and result in hypernatremia, hypokalemia, hyperosmolality, edema and aggravation of congestive heart failure. Therapy with sodium- containing alkalinizing agents should not be used in patients with hypernatremia or fluid retention. Clinical monitoring of acid/base balance and electrolytes prior to, during, a following completion of therapy with alkalinizing agents is recommended.

References

  1. "Product Information. Sodium Bicarbonate (sodium bicarbonate)." Astra-Zeneca Pharmaceuticals PROD (2001):
  2. "Product Information. Sodium Lactate (sodium lactate)." Abbott Pharmaceutical PROD (2001):
Major

Laxatives (applies to Phosphate Laxative) inflammatory bowel disease

Major Potential Hazard, Moderate plausibility.

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

References

  1. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc PROD (2001):
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet PROD
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb PROD
  4. "Product Information. Neoloid (castor oil)." Paddock Laboratories Inc PROD (2001):
  5. "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
  6. "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):
View all 6 references
Major

Laxatives (applies to Phosphate Laxative) intestinal obstruction disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction, Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

References

  1. "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc PROD (2001):
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet PROD
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb PROD
  4. "Product Information. Fleet Mineral Oil Enema (mineral oil)." Fleet PROD (2001):
  5. "Product Information. Citrucel (methylcellulose)." SmithKline Beecham PROD (2001):
  6. "Product Information. Fleet Babylax (glycerin)." Alcon Laboratories Inc PROD (2001):
  7. "Product Information. SenoSol-X (senna)." Apothecon Inc (2022):
  8. "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories (2010):
View all 8 references
Major

Phosphates (applies to Phosphate Laxative) hypocalcemia

Major Potential Hazard, High plausibility. Applicable conditions: Pancreatitis, Hyperkalemia, Pancreatitis

The use of phosphates is in general contraindicated in conditions where high potassium, high phosphate, or low calcium may be encountered such as hypoparathyroidism, osteomalacia, acute pancreatitis, or chronic renal disease.

References

  1. "Product Information. K-Phos Neutral (potassium phosphate)." Beach Pharmaceuticals PROD (2001):
  2. "Product Information. Fleet Enema (sodium acid phophate-sodium phosphate)." Fleet PROD (2001):
Major

Phosphates (applies to Phosphate Laxative) phosphate imbalance

Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Hypoparathyroidism, Hypoparathyroidism, Renal Dysfunction

Therapy with phosphates should be administered with extreme caution in patients with hyperphosphatemia (hypoparathyroidism or severe renal impairment). Elevated serum concentrations of phosphate and calcium can exceed the solubility level and result in calcium-phosphate precipitates that deposit in vascular and renal systems as well as other soft tissues of the body. Clinical monitoring of serum calcium and phosphate concentrations is necessary.

References

  1. "Product Information. K-Phos Neutral (potassium phosphate)." Beach Pharmaceuticals PROD (2001):
  2. "Product Information. Fleet Enema (sodium acid phophate-sodium phosphate)." Fleet PROD (2001):
Major

Sodium phosphate (applies to Phosphate Laxative) electrolyte imbalance

Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure, Dehydration, Phosphate Imbalance, Gastrointestinal Obstruction, Inflammatory Bowel Disease, Dehydration, Congestive Heart Failure, Phosphate Imbalance, Gastrointestinal Obstruction, Inflammatory Bowel Disease

The use of sodium phosphates is contraindicated in patients with congenital megacolon, intestinal obstruction, imperforate anus, active inflammatory disease or congestive heart failure. Serious, potentially life-threatening electrolyte imbalance such as hypocalcemia and hyperphosphatemia can result with prolonged or excessive use of phosphate laxatives. Hypernatremia and dehydration can occur due to improper dilution of hypertonic saline laxatives. Therapy with sodium phosphates should be administered cautiously and frequency of administration limited in patients with renal dysfunction, colostomy, cardiac dysfunction, or electrolyte imbalance. Clinical monitoring of electrolyte concentrations is recommended.

References

  1. "Product Information. Magnesium Sulfate (magnesium sulfate)." Abbott Pharmaceutical PROD (2001):
  2. "Product Information. Fleet Enema (sodium acid phophate-sodium phosphate)." Fleet PROD (2001):

Phosphate Laxative drug interactions

There are 401 drug interactions with Phosphate Laxative (sodium biphosphate / sodium phosphate).

Phosphate Laxative alcohol/food interactions

There is 1 alcohol/food interaction with Phosphate Laxative (sodium biphosphate / sodium phosphate).

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More about Phosphate Laxative (sodium biphosphate / sodium phosphate)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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