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Rapaflo (silodosin) Disease Interactions

There are 3 disease interactions with Rapaflo (silodosin):

Major

Silodosin (Includes Rapaflo) ↔ Hepatic Impairment

Severe Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The use of silodosin is contraindicated in patients with severe hepatic impairment. No dosage adjustment is needed in patients with mild or moderate hepatic impairment.

Major

Silodosin (Includes Rapaflo) ↔ Severe Renal Impairment

Severe Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

The use of silodosin is contraindicated in patients with severe renal impairment (CrCl < 30 mL/min). Caution and regular monitoring is recommended in patients with moderate renal impairment as the plasma concentrations can increase three times higher when compared with subjects with normal renal function. Dose should be reduced to 4 mg/day in patients with moderate renal impairment.

Moderate

Antiadrenergic Agents (Includes Rapaflo) ↔ Cataracts

Moderate Potential Hazard, Moderate plausibility

Applies to: Cataracts

Intraoperative Floppy Iris Syndrome has been observed during cataract surgery in some patients on or previously treated with antiadrenergic agents. If a patient is undergoing cataract surgery, the ophthalmologist should be prepared for possible modifications of the surgical technique (iris hooks, iris dilator rings). There does not appear to be a benefit in stopping antiadrenergic agents therapy prior to the cataracts surgery.

Rapaflo (silodosin) drug Interactions

There are 492 drug interactions with Rapaflo (silodosin)

Rapaflo (silodosin) alcohol/food Interactions

There are 2 alcohol/food interactions with Rapaflo (silodosin)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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