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Xpovio (selinexor) Disease Interactions

There are 8 disease interactions with Xpovio (selinexor):

Moderate

Selinexor (applies to Xpovio) GI toxicities

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Dehydration, Diarrhea, Vomiting

The use of selinexor can cause gastrointestinal toxicities. Manage nausea/vomiting/diarrhea by dose interruption, reduction, or discontinuation. Administer intravenous fluids and replace electrolytes to prevent dehydration in patients at risk. Use anti-nausea and anti-diarrheal medications as clinically indicated.

Moderate

Selinexor (applies to Xpovio) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Selinexor is metabolized by CYP450 3A4, multiple UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs). Care is recommended when using this agent in patients with moderate to severe hepatic impairment. The effect of moderate and severe hepatic impairment on selinexor pharmacokinetics is unknown. Mild hepatic impairment had no clinically significant effect on the pharmacokinetics of selinexor.

Moderate

Selinexor (applies to Xpovio) hyponatremia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus

The use of selinexor can cause hyponatremia. Exercise care when using this agent in patients with hyperglycemia and high serum paraprotein levels. It is recommended to treat hyponatremia per clinical guidelines and to assess hydration and dietary intake. Interrupt or reduce dose, or permanently discontinue treatment based on severity.

Moderate

Selinexor (applies to Xpovio) neurological toxicities

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Dehydration, Anemia

The use of selinexor may cause neurological toxicities. Exercise care when using this agent in dehydrated patients and those with anemia. It is recommended to optimize hydration status and hemoglobin levels to avoid exacerbation of dizziness or mental changes.

Moderate

Selinexor (applies to Xpovio) neutropenia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral

The use of selinexor can cause neutropenia. Exercise care when using this agent in neutropenic patients and those at risk of infections. Monitor patients for signs and symptoms of concomitant infection, evaluate promptly, and institute measures according to clinical practice. Interrupt treatment, reduce dose, or permanently discontinue based on severity.

Moderate

Selinexor (applies to Xpovio) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

No clinically significant differences in the pharmacokinetics of selinexor were observed in patients with mild to severe renal impairment (CrCl 15 to 89 mL/min, estimated by the Cockcroft-Gault equation). Care is recommended when using this agent in patients with end-stage renal disease (CrCl <15 mL/min) or hemodialysis as the effect on selinexor pharmacokinetics is unknown for these patients.

Moderate

Selinexor (applies to Xpovio) thrombocytopenia

Moderate Potential Hazard, Moderate plausibility.

The use of selinexor can cause thrombocytopenia. Exercise care when using this agent in thrombocytopenic patients and those at risk of fatal hemorrhages. Monitor platelet counts at baseline and periodically as clinically indicated. Monitor for signs and symptoms of bleeding and interrupt or reduce the dose or permanently discontinue treatment based on severity.

Moderate

Selinexor (applies to Xpovio) weight loss

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Weight Loss/Failure to Thrive, Anorexia/Feeding Problems

The use of selinexor can cause anorexia and weight loss. Exercise care in patients with anorexia and those at risk for weight loss. Manage with dose modifications, appetite stimulants, and nutritional support. Monitor patient weight at baseline, and regularly during treatment as clinically indicated.

Xpovio (selinexor) drug interactions

There are 120 drug interactions with Xpovio (selinexor)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.