Skip to main content

Kevzara Disease Interactions

There are 7 disease interactions with Kevzara (sarilumab).

Major

Sarilumab (applies to Kevzara) infections

Major Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral

Serious and sometimes fatal infections due to bacterial, mycobacterial, invasive fungal, viral, or other opportunistic pathogens have been reported in rheumatoid arthritis patients receiving sarilumab; the most common serious infections reported included pneumonia and cellulitis. Use of sarilumab should be avoided in patients with an active infection, including localized infections. The risks and benefits of treatment should be considered before starting sarilumab in patients: with chronic/recurrent infection, who have been exposed to tuberculosis, with history of serious/opportunistic infection, who have resided/traveled in areas of endemic tuberculosis/mycoses, or with underlying conditions that may predispose them to infection. Patients should be closely monitored for signs/symptoms of infection during sarilumab treatment as signs/symptoms of acute inflammation may be reduced due to suppression of acute phase reactants. If a serious infection or an opportunistic infection develops, sarilumab should be interrupted until the infection is controlled. A patient who develops a new infection during treatment with sarilumab should undergo prompt and complete diagnostic testing appropriate for an immunocompromised patient; appropriate antimicrobial therapy should be started, and the patient should be monitored closely.

References

  1. (2018) "Product Information. Kevzara (sarilumab)." sanofi-aventis, SUPPL-1
Major

Sarilumab (applies to Kevzara) tuberculosis

Major Potential Hazard, Moderate plausibility. Applicable conditions: History - Tuberculosis, Tuberculosis -- Active, Tuberculosis -- Latent

Sarilumab should not be given to patients with active tuberculosis (TB) infection. Patients should be evaluated for TB risk factors and tested for latent infection before starting sarilumab and during therapy; if positive for latent TB, patients should be treated with standard antimycobacterial therapy before starting sarilumab. Anti-TB therapy should be considered prior to starting sarilumab in patients with history of latent/active TB in whom an adequate course of treatment cannot be confirmed, and for patients with a negative test for latent TB but having risk factors for TB infection. Consultation with a physician with expertise in TB may be appropriate when considering anti-TB therapy. Patients should be closely monitored for signs/symptoms of TB, including patients who tested negative for latent TB infection prior to initiating therapy.

References

  1. (2018) "Product Information. Kevzara (sarilumab)." sanofi-aventis, SUPPL-1
Moderate

Sarilumab (applies to Kevzara) blood disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: History - Blood Dyscrasias, Thrombocytopenia, Neutropenia

The use of sarilumab is associate with higher incidence of decrease in absolute neutrophil count (ANC), including neutropenia and thrombocytopenia. It is recommended to assess neutrophil count and platelet count prior to initiation of therapy and monitor these levels 4 to 8 weeks after start of therapy and every 3 months thereafter. Dose modification may be necessary based on the pharmacodynamics of the changes in ANC. Care is recommended when using this agent in patients with blood disorders.

References

  1. (2017) "Product Information. Kevzara (sarilumab)." sanofi-aventis
Moderate

Sarilumab (applies to Kevzara) diverticulitis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Diverticula, Gastrointestinal Obstruction

Gastrointestinal (GI) perforations have been reported with the use of sarilumab. GI perforation risk may be increased with concurrent diverticulitis or concomitant use of NSAIDs or corticosteroids. Assess patients for gastrointestinal complications prior to beginning therapy and promptly evaluate patients presenting with new onset abdominal symptoms.

References

  1. (2017) "Product Information. Kevzara (sarilumab)." sanofi-aventis
Moderate

Sarilumab (applies to Kevzara) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of sarilumab is associate with transaminase elevations; therefore, treatment with sarilumab is not recommended in patients with active hepatic disease or hepatic impairment. It is recommended to assess ALT/AST levels prior to initiation of treatment and monitor ALT and AST levels 4 to 8 weeks after start of therapy and every 3 months thereafter. When clinically indicated, consider other liver function tests such as bilirubin. Dose modification based on transaminase elevations might be warranted. The safety and efficacy or sarilumab have not been conducted in patients with hepatic impairment, including patients with positive HBV or HCV serology.

References

  1. (2017) "Product Information. Kevzara (sarilumab)." sanofi-aventis
Moderate

Sarilumab (applies to Kevzara) hyperlipidemia

Moderate Potential Hazard, Moderate plausibility.

The use of sarilumab is associate with increases in lipid parameters such as LDL cholesterol, HDL cholesterol and/or triglycerides. Care should be exercised when using this agent in patients with lipid abnormalities. It is recommended to assess lipid parameters at baseline and parameters approximately 4 to 8 weeks following initiation of treatment, then at approximately 6 months intervals.

References

  1. (2017) "Product Information. Kevzara (sarilumab)." sanofi-aventis
Moderate

Sarilumab (applies to Kevzara) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Monoclonal antibodies, including sarilumab, are not eliminated via renal pathway. No dose adjustment is required in patients with mild to moderate renal impairment. The use of sarilumab has not been evaluated in patients with severe renal impairment. Care should be exercised.

References

  1. (2017) "Product Information. Kevzara (sarilumab)." sanofi-aventis

Kevzara drug interactions

There are 264 drug interactions with Kevzara (sarilumab).

Kevzara alcohol/food interactions

There is 1 alcohol/food interaction with Kevzara (sarilumab).


Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.