Pyrimethamine Disease Interactions
There are 4 disease interactions with pyrimethamine.
Pyrimethamine (applies to pyrimethamine) folate deficiency
Major Potential Hazard, High plausibility. Applicable conditions: Malabsorption Syndrome, Acute Alcohol Intoxication, Anemia Associated with Folate Deficiency
Pyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.
Pyrimethamine (applies to pyrimethamine) liver disease
Moderate Potential Hazard, Moderate plausibility.
Pyrimethamine is extensively metabolized by the liver. Therapy with pyrimethamine should be administered cautiously in patients with liver disease.
Pyrimethamine (applies to pyrimethamine) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Pyrimethamine and its metabolites are excreted in the urine. Therapy with pyrimethamine should be administered cautiously in patients with renal dysfunction.
Pyrimethamine (applies to pyrimethamine) seizure disorders
Moderate Potential Hazard, High plausibility. Applicable conditions: Seizures
The use of pyrimethamine has been associated with ataxia, tremors, and seizures. Therapy with pyrimethamine should be administered cautiously and in lower dosages in patients with seizure disorders.
Switch to professional interaction data
Pyrimethamine drug interactions
There are 29 drug interactions with pyrimethamine.
Report options
More about pyrimethamine
- pyrimethamine consumer information
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (1)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: miscellaneous antimalarials
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Plaquenil
Plaquenil is used to treat or prevent malaria and to treat the symptoms of rheumatoid arthritis ...
Vibramycin
Vibramycin is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Monodox
Monodox is used for acne, actinomycosis, amebiasis, anthrax, anthrax prophylaxis, bacterial ...
Malarone
Malarone (atovaquone and proguanil) is an antiprotozoal and antimalarial and is used to treat or ...
Primaquine
Primaquine is used for malaria, malaria prevention, pneumocystis pneumonia
Atovaquone/proguanil
Atovaquone/proguanil is used for malaria, malaria prevention
Chloroquine
Chloroquine is used for amebiasis, malaria, malaria prevention, sarcoidosis
Hydroxychloroquine
Hydroxychloroquine is a quinoline drug used to treat or prevent malaria. It's also used to treat ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
