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Pyrimethamine Disease Interactions

There are 4 disease interactions with pyrimethamine.

Major

Pyrimethamine (applies to pyrimethamine) folate deficiency

Major Potential Hazard, High plausibility. Applicable conditions: Malabsorption Syndrome, Acute Alcohol Intoxication, Anemia Associated with Folate Deficiency

Pyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.

References

  1. (2001) "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome
Moderate

Pyrimethamine (applies to pyrimethamine) liver disease

Moderate Potential Hazard, Moderate plausibility.

Pyrimethamine is extensively metabolized by the liver. Therapy with pyrimethamine should be administered cautiously in patients with liver disease.

References

  1. (2001) "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome
Moderate

Pyrimethamine (applies to pyrimethamine) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Pyrimethamine and its metabolites are excreted in the urine. Therapy with pyrimethamine should be administered cautiously in patients with renal dysfunction.

References

  1. (2001) "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome
Moderate

Pyrimethamine (applies to pyrimethamine) seizure disorders

Moderate Potential Hazard, High plausibility. Applicable conditions: Seizures

The use of pyrimethamine has been associated with ataxia, tremors, and seizures. Therapy with pyrimethamine should be administered cautiously and in lower dosages in patients with seizure disorders.

References

  1. (2001) "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome

Pyrimethamine drug interactions

There are 28 drug interactions with pyrimethamine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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