Pyrimethamine Disease Interactions
There are 4 disease interactions with pyrimethamine.
Pyrimethamine (applies to pyrimethamine) folate deficiency
Major Potential Hazard, High plausibility. Applicable conditions: Malabsorption Syndrome, Acute Alcohol Intoxication, Anemia Associated with Folate Deficiency
Pyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.
Pyrimethamine (applies to pyrimethamine) liver disease
Moderate Potential Hazard, Moderate plausibility.
Pyrimethamine is extensively metabolized by the liver. Therapy with pyrimethamine should be administered cautiously in patients with liver disease.
Pyrimethamine (applies to pyrimethamine) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Pyrimethamine and its metabolites are excreted in the urine. Therapy with pyrimethamine should be administered cautiously in patients with renal dysfunction.
Pyrimethamine (applies to pyrimethamine) seizure disorders
Moderate Potential Hazard, High plausibility. Applicable conditions: Seizures
The use of pyrimethamine has been associated with ataxia, tremors, and seizures. Therapy with pyrimethamine should be administered cautiously and in lower dosages in patients with seizure disorders.
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Pyrimethamine drug interactions
There are 29 drug interactions with pyrimethamine.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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