Photofrin Disease Interactions
There are 3 disease interactions with Photofrin (porfimer).
Porfimer (applies to Photofrin) esophageal fistula
Major Potential Hazard, High plausibility. Applicable conditions: Tracheoesophageal Fistula
The use of photodynamic therapy (PDT) with porfimer is contraindicated for the treatment of esophageal cancer in patients with an existing bronchoesophageal or tracheoesophageal fistula. Prior to administration of PDT, patients must be evaluated by barium swallow to rule out fistulas, which can occur with PDT, particularly if the esophageal tumor is eroding into the trachea or bronchial tree.
Porfimer (applies to Photofrin) esophageal varices
Major Potential Hazard, High plausibility.
Treatment with photodynamic therapy and porfimer should be conducted with extreme caution in patients with esophageal varices. Light should not be given directly to the variceal area because of the high risk of bleeding. In general, photodynamic therapy is not suitable for patients with esophageal or gastric varices, or patients with esophageal ulcers >1 cm in diameter.
Porfimer (applies to Photofrin) porphyria
Major Potential Hazard, High plausibility.
The use of porfimer is contraindicated in patients with porphyria.
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Photofrin drug interactions
There are 210 drug interactions with Photofrin (porfimer).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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