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Phenazopyridine Disease Interactions

There are 3 disease interactions with phenazopyridine:

Major

Phenazopyridine (Includes phenazopyridine) ↔ G-6-PD deficiency

Severe Potential Hazard, Moderate plausibility. Applies to: G-6-PD Deficiency

Patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may be at increased risk for phenazopyridine-induced methemoglobinemia and hemolytic anemia. These conditions have occurred rarely in other patients, except due to acute phenazopyridine overdose or impaired renal function. Therapy with phenazopyridine should be administered cautiously in patients with G-6-PD deficiency.

References

  1. "Product Information. Pyridium (phenazopyridine)." Warner Chilcott Laboratories, Rockaway, NJ.
Major

Phenazopyridine (Includes phenazopyridine) ↔ hepatitis

Severe Potential Hazard, Moderate plausibility. Applies to: Liver Disease

The use of phenazopyridine is contraindicated in patients with severe hepatitis. Rare cases of hepatotoxicity have been associated with phenazopyridine, usually at overdose levels. Hypersensitivity hepatitis has also been reported. Therapy with phenazopyridine should be administered cautiously in patients with impaired hepatic function.

References

  1. "Product Information. Pyridium (phenazopyridine)." Warner Chilcott Laboratories, Rockaway, NJ.
Major

Phenazopyridine (Includes phenazopyridine) ↔ renal dysfunction

Severe Potential Hazard, High plausibility. Applies to: Renal Dysfunction

The use of phenazopyridine is contraindicated in patients with impaired renal function. Phenazopyridine is primarily eliminated unchanged by the kidney and may accumulate to toxic levels during prolonged administration in such patients. Reported cases of toxicity due to overdosage have resulted in acute renal failure and methemoglobinemia. Likewise, administration of phenazopyridine to patients with preexisting renal failure has led to methemoglobinemia and hemolytic anemia. Phenazopyridine toxicity may be associated with a yellowish tinge of the skin or sclera.

References

  1. "Product Information. Pyridium (phenazopyridine)." Warner Chilcott Laboratories, Rockaway, NJ.

Phenazopyridine drug interactions

There are 27 drug interactions with phenazopyridine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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