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Octreotide Disease Interactions

There are 3 disease interactions with octreotide:

Major

Octreotide (Includes Octreotide) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Octreotide is eliminated by the kidney. Approximately 30% of octreotide is excreted unchanged in the urine, The serum concentration of octreotide and the half-life is increased in patients with severe renal dysfunction. Therapy with octreotide should be administered cautiously and dosage modification considered in patients with severe renal impairment as the half-life of octreotide may be increased, necessitating adjustment of the dosage.

References

  1. "Product Information. Sandostatin (octreotide)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Moderate

Octreotide (Includes Octreotide) ↔ Cv Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Cardiovascular Disease, Congestive Heart Failure, Heart Disease, Arrhythmias

Bradycardia, arrhythmias and conduction abnormalities, including QT prolongation have been reported with the use of octreotide. Patients taking others drugs that have bradycardic effects may need dose adjustments. Caution is recommended in patients with cardiac function abnormalities.

Moderate

Octreotide (Includes Octreotide) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

The half-life of octreotide may be increased in patients with liver cirrhosis, necessitating adjustment of dosage. This dose should be up titrated based on clinical response and speed of response as deemed necessary by the physician.

octreotide drug Interactions

There are 162 drug interactions with octreotide

octreotide alcohol/food Interactions

There is 1 alcohol/food interaction with octreotide

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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