Levophed Disease Interactions
There are 3 disease interactions with Levophed (norepinephrine).
Norepinephrine (applies to Levophed) peripheral vascular thrombosis
Major Potential Hazard, Moderate plausibility. Applicable conditions: Peripheral Arterial Disease
Norepinephrine injection should not be given to patients with mesenteric or peripheral vascular thrombosis (because of the risk of increasing ischemia and extending the area of infarction) unless, in the opinion of the attending physician,the administration of norepinephrine is necessary as a life- saving procedure.
Sympathomimetics (applies to Levophed) dehydration
Major Potential Hazard, High plausibility.
The use of sympathomimetic amines has been infrequently associated with significant hypotension especially in dehydrated patients secondary to the drug's beta-2 mediated vasodilation. Hypovolemia should be corrected, if possible, before administering sympathomimetic amines. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.
Sympathomimetics (applies to Levophed) acidosis
Moderate Potential Hazard, High plausibility.
Acidosis, hypoxia, and hypercapnia may reduce the effectiveness of sympathomimetic amines in raising blood pressure. These conditions should be corrected before initiating therapy with sympathomimetic amines, if possible. Monitoring the patients acid-base balance, carbon dioxide levels, and oxygen saturation is recommended.
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Levophed drug interactions
There are 192 drug interactions with Levophed (norepinephrine).
Levophed alcohol/food interactions
There is 1 alcohol/food interaction with Levophed (norepinephrine).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.