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Minoxidil topical Disease Interactions

There is 1 disease interaction with minoxidil topical.


Minoxidil topical (applies to minoxidil topical) systemic effects

Moderate Potential Hazard, Low plausibility. Applicable conditions: Congestive Heart Failure, Fluid Retention, Sunburn, Arrhythmias, Ischemic Heart Disease

In general, topically applied minoxidil is poorly absorbed from the normal, intact scalp. However, alteration in scalp epidermal integrity (e.g., abrasion, sunburn, psoriasis) can increase percutaneous absorption with resultant systemic effects, including sodium and water retention, local or generalized edema, pericardial effusion, pericarditis, tamponade, tachycardia, and worsening or development of angina. Therapy with minoxidil should be avoided in patients with diminished or altered scalp integrity that may lead to enhanced systemic absorption, particularly in the presence of underlying cardiovascular dysfunction or fluid retention.


  1. Leenen FH, Smith DL, Unger WP "Topical minoxidil: cardiac effects in bald men." Br J Clin Pharmacol 26 (1988): 481-5
  2. Woodside J Jr, Garner L, Beford RF, et al. "Captopril reduces the dose requirement for sodium nitroprusside induced hypotension." Anesthesiology 60 (1984): 413-7
  3. Whitmore SE, Wigley FM, Wise RA "Acute effect of topical minoxidil on digital blood flow in patients with raynaud's phenomenon." J Rheumatol 22 (1995): 50-4
  4. "PDR Generics." Montvale, NJ: Medical Economics (1995):
View all 4 references

Minoxidil topical drug interactions

There are 38 drug interactions with minoxidil topical.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.