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Mustargen (mechlorethamine) Disease Interactions

There is 1 disease interaction with Mustargen (mechlorethamine):


Mechlorethamine (Includes Mustargen) ↔ Myelosuppression

Moderate Potential Hazard, Moderate plausibility

Applies to: Bleeding, Fever, Bone Marrow Depression/Low Blood Counts

Mechlorethamine induces leukopenia and thrombocytopenia. Therapy should be administered cautiously in patients whose bone marrow reserve may be severely depressed by prior irradiation or chemotherapy, or whose marrow function is recovering from previous cytotoxic therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Other unspecified bone marrow abnormalities have been noted during therapy with mechlorethamine in patients with neoplastic disease. Close clinical monitoring of hematopoietic function is recommended.


  1. "Product Information. Mustargen (mechlorethamine)." Merck & Co, Inc, West Point, PA.

Mustargen (mechlorethamine) drug Interactions

There are 166 drug interactions with Mustargen (mechlorethamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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