Magaldrate/simethicone Disease Interactions
There are 3 disease interactions with magaldrate / simethicone.
Aluminum-containing antacids (applies to magaldrate/simethicone) constipation
Major Potential Hazard, High plausibility. Applicable conditions: Renal Dysfunction, Intestinal Obstruction, Phosphate Imbalance
Aluminum containing antacids may produce constipation, which may lead to intestinal obstruction. Osteomalacia and hypophosphatemia may be produced in patients with renal dysfunction who are not receiving dialysis. Patients with renal dysfunction, intestinal obstruction, osteomalacia, or hypophosphatemia should use antacids with low or no aluminum content.
Magnesium salts (applies to magaldrate/simethicone) renal dysfunction
Major Potential Hazard, High plausibility.
Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.
Magnesium-containing antacids (applies to magaldrate/simethicone) diarrhea
Moderate Potential Hazard, Moderate plausibility.
The use of magnesium-containing antacids has been associated with a laxative effect and may cause diarrhea. Therapy with magnesium-containing antacids should be administered cautiously in patients with diarrhea.
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Magaldrate/simethicone drug interactions
There are 231 drug interactions with magaldrate / simethicone.
More about magaldrate / simethicone
- Check interactions
- Compare alternatives
- Reviews (2)
- Side effects
- Dosage information
- During pregnancy
- Drug class: antacids
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.