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Lumasiran Disease Interactions

There are 2 disease interactions with lumasiran.

Moderate

Lumasiran (applies to lumasiran) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal [3 x ULN] with any AST). No dose adjustment is recommended for patients with mild (total bilirubin greater than 1 to 1.5 x ULN or AST greater than 1 x ULN) or moderate (total bilirubin greater than 1.5 to 3 x ULN with any AST) liver dysfunction.

Moderate

Lumasiran (applies to lumasiran) renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: peritoneal dialysis

Lumasiran has not been studied in patients on peritoneal dialysis. No dose adjustment is needed in patients with renal dysfunction, including patients with renal failure treated with hemodialysis.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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