Lumasiran Disease Interactions
There are 2 disease interactions with lumasiran.
Lumasiran (applies to lumasiran) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal [3 x ULN] with any AST). No dose adjustment is recommended for patients with mild (total bilirubin greater than 1 to 1.5 x ULN or AST greater than 1 x ULN) or moderate (total bilirubin greater than 1.5 to 3 x ULN with any AST) liver dysfunction.
Lumasiran (applies to lumasiran) renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: peritoneal dialysis
Lumasiran has not been studied in patients on peritoneal dialysis. No dose adjustment is needed in patients with renal dysfunction, including patients with renal failure treated with hemodialysis.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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