Lumasiran Disease Interactions
There are 2 disease interactions with lumasiran:
Lumasiran (Includes lumasiran) ↔ liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal with any AST). Caution is recommended if used in these patients.
Lumasiran (Includes lumasiran) ↔ renal dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
Lumasiran has not been studied in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2 or patients on dialysis. Caution is recommended if used in these patients.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.