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Lumasiran Disease Interactions

There are 2 disease interactions with lumasiran:

Moderate

Lumasiran (Includes lumasiran) ↔ liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal with any AST). Caution is recommended if used in these patients.

Moderate

Lumasiran (Includes lumasiran) ↔ renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Lumasiran has not been studied in patients with estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2 or patients on dialysis. Caution is recommended if used in these patients.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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