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Generic name: lumasiranLOO-ma-SIR-an ]
Drug class: Miscellaneous metabolic agents

Medically reviewed by on Jan 1, 2024. Written by Cerner Multum.

What is Oxlumo?

Oxlumo is used to treat a type of hyperoxaluria (high levels of oxalate in your urine). Oxalate is a natural chemical contained in the body and in certain foods. Too much oxalate in the urine can cause kidney stones or kidney failure.

Oxlumo is for use in adults and children of all ages.

Oxlumo may also be used for purposes not listed in this medication guide.

Oxlumo side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include pain, redness, itching, or swelling where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You may need to follow a special diet to help control your condition.

Before taking this medicine

Tell your doctor if you are pregnant or breastfeeding.

How is Oxlumo given?

Oxlumo is injected under the skin.

A healthcare provider will give you this injection.

Oxlumo is usually given once every 1 to 3 months.

Oxlumo doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight.

You may need to follow a special diet. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Oxlumo.

What happens if I overdose?

Since Oxlumo is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while using Oxlumo?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Oxlumo?

Other drugs may affect Oxlumo, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.