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Lumasiran Disease Interactions

There are 2 disease interactions with lumasiran.

Moderate

Lumasiran (applies to lumasiran) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Lumasiran has not been studied in patients with severe liver dysfunction (total bilirubin greater than 3 times the upper limit of normal [3 x ULN] with any AST). No dose adjustment is recommended for patients with mild (total bilirubin greater than 1 to 1.5 x ULN or AST greater than 1 x ULN) or moderate (total bilirubin greater than 1.5 to 3 x ULN with any AST) liver dysfunction.

References (1)
  1. (2023) "Product Information. Oxlumo (lumasiran)." Alnylam Pharmaceuticals, SUPPL-4
Moderate

Lumasiran (applies to lumasiran) renal dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: peritoneal dialysis

Lumasiran has not been studied in patients on peritoneal dialysis. No dose adjustment is needed in patients with renal dysfunction, including patients with renal failure treated with hemodialysis.

References (1)
  1. (2023) "Product Information. Oxlumo (lumasiran)." Alnylam Pharmaceuticals, SUPPL-4

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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