Lumasiran Dosage
Medically reviewed by Drugs.com. Last updated on Jan 2, 2025.
Applies to the following strengths: 94.5 mg/0.5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Primary Hyperoxaluria
At least 20 kg:
- Loading dose: 3 mg/kg subcutaneously once a month for 3 doses
- Maintenance dose: 3 mg/kg subcutaneously every 3 months (quarterly)
Use: For the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary and plasma oxalate levels
Usual Pediatric Dose for Primary Hyperoxaluria
Less than 10 kg:
- Loading dose: 6 mg/kg subcutaneously once a month for 3 doses
- Maintenance dose: 3 mg/kg subcutaneously once a month
10 to less than 20 kg:
- Loading dose: 6 mg/kg subcutaneously once a month for 3 doses
- Maintenance dose: 6 mg/kg subcutaneously every 3 months (quarterly)
At least 20 kg:
- Loading dose: 3 mg/kg subcutaneously once a month for 3 doses
- Maintenance dose: 3 mg/kg subcutaneously every 3 months (quarterly)
Use: For the treatment of PH1 to lower urinary and plasma oxalate levels
Renal Dose Adjustments
Estimated GFR at least 30 mL/min/1.73 m2: No adjustment recommended.
Estimated GFR less than 30 mL/min/1.73 m2: Data not available
Liver Dose Adjustments
Mild or moderate liver dysfunction: No adjustment recommended.
Severe liver dysfunction: Data not available
Comments:
- Mild liver dysfunction: Total bilirubin greater than the upper limit of normal (ULN) to 1.5 times the ULN (1.5 x ULN) or AST greater than ULN
- Moderate liver dysfunction: Total bilirubin greater than 1.5 to 3 x ULN with any AST
- Severe liver dysfunction: Total bilirubin greater than 3 x ULN with any AST
Precautions
CONTRAINDICATIONS: None
Consult WARNINGS section for additional precautions.
Dialysis
This drug should be administered after hemodialysis if administered on dialysis days.
Other Comments
Administration advice:
- For subcutaneous use
- Divide injection volumes greater than 1.5 mL equally into multiple syringes.
- Use a sterile 0.3-mL syringe for volumes less than 0.3 mL.
- Administer subcutaneous injection into the abdomen, thigh, or the side/back of the upper arms; rotate injection sites; do not inject into scar tissue or reddened/inflamed/swollen areas.
- If injecting into the abdomen, avoid the area around the navel.
- If more than 1 injection is needed for a single dose, ensure injection sites are at least 2 centimeters apart.
- If dose is delayed/missed, administer as soon as possible; resume prescribed monthly or quarterly dosing from most recently administered dose.
Storage requirements:
- Store at 2C to 25C (36F to 77F).
- Store in original container until ready for use.
General:
- Dosing is based on actual body weight.
- This drug should be administered by a healthcare professional.
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