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Lumasiran Dosage

Medically reviewed by Drugs.com. Last updated on Jan 12, 2021.

Applies to the following strengths: 94.5 mg/0.5 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Primary Hyperoxaluria

At least 20 kg:
-Loading dose: 3 mg/kg subcutaneously once a month for 3 doses
-Maintenance dose: 3 mg/kg subcutaneously every 3 months (quarterly)

Use: For the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate levels

Usual Pediatric Dose for Primary Hyperoxaluria

Less than 10 kg:
-Loading dose: 6 mg/kg subcutaneously once a month for 3 doses
-Maintenance dose: 3 mg/kg subcutaneously once a month

10 to less than 20 kg:
-Loading dose: 6 mg/kg subcutaneously once a month for 3 doses
-Maintenance dose: 6 mg/kg subcutaneously every 3 months (quarterly)

At least 20 kg:
-Loading dose: 3 mg/kg subcutaneously once a month for 3 doses
-Maintenance dose: 3 mg/kg subcutaneously every 3 months (quarterly)

Use: For the treatment of PH1 to lower urinary oxalate levels

Renal Dose Adjustments

Estimated GFR at least 30 mL/min/1.73 m2: No adjustment recommended.
Estimated GFR less than 30 mL/min/1.73 m2: Data not available

Liver Dose Adjustments

Mild or moderate liver dysfunction: No adjustment recommended.
Severe liver dysfunction: Data not available

Comments:
-Mild liver dysfunction: Total bilirubin greater than the upper limit of normal (ULN) to 1.5 times the ULN (1.5 x ULN) or AST greater than ULN
-Moderate liver dysfunction: Total bilirubin greater than 1.5 to 3 x ULN with any AST
-Severe liver dysfunction: Total bilirubin greater than 3 x ULN with any AST

Precautions

CONTRAINDICATIONS: None

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-For subcutaneous use
-Divide injection volumes greater than 1.5 mL equally into multiple syringes.
-Use a sterile 0.3-mL syringe for volumes less than 0.3 mL.
-Administer subcutaneous injection into the abdomen, thigh, or the side/back of the upper arms; rotate injection sites; do not inject into scar tissue or reddened/inflamed/swollen areas.
---If injecting into the abdomen, avoid the area around the navel.
---If more than 1 injection is needed for a single dose, ensure injection sites are at least 2 centimeters apart.
-If dose is delayed/missed, administer as soon as possible; resume prescribed monthly or quarterly dosing from most recently administered dose.

Storage requirements:
-Store at 2C to 25C (36F to 77F).
-Store in original container until ready for use.

General:
-Dosing is based on actual body weight.
-This drug should be administered by a healthcare professional.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.