Lumasiran Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 29, 2025.

Applies to lumasiran: subcutaneous solution.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly to check for unwanted effects.

Common side effects of lumasiran

Some side effects of lumasiran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of lumasiran

Along with its needed effects, lumasiran may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

For healthcare professionals

Applies to lumasiran: subcutaneous solution.

General adverse events

The most common adverse reaction reported was injection site reaction.^[Ref]

Gastrointestinal

• Very common (10% or more): Abdominal pain (up to 16.3%)

Abdominal pain included abdominal pain, upper abdominal pain, lower abdominal pain, abdominal discomfort, and abdominal tenderness.

Hypersensitivity

• Postmarketing reports: Hypersensitivity

Immunologic

• Common (1% to 10%): Positive for antidrug antibodies

Antidrug antibody titers were low and generally transient. No clinically significant differences in efficacy, safety, pharmacokinetic, or pharmacodynamic profiles of this drug were observed in patients who tested positive for antidrug antibodies.

Local

• Very common (10% or more): Injection site reaction (up to 38%)

Injection site reaction included injection site: reaction, erythema, pain, pruritus, swelling, discomfort, discoloration, mass, induration, rash, bruising, hematoma, and exfoliation.

During clinical studies, injection site reactions occurred in 34 of 98 patients. The most commonly reported symptoms included erythema, swelling, pain, hematoma, pruritus, and discoloration. Most injection site reactions started on the day of administration; less than 2% occurred 5 or more days after administration. Injection site reactions were generally mild, resolved within 2 days, and did not lead to interruption/discontinuation of therapy.

See also:

Further information

Lumasiran side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer