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Isovue-300 (iopamidol) Disease Interactions

There are 10 disease interactions with Isovue-300 (iopamidol):

Major

Iodinated radiopaque contrast agents (applies to Isovue-300) hyperthyroidism

Major Potential Hazard, Moderate plausibility.

Reports of thyroid storm following the use of iodinated diagnostic agents in patients with hyperthyroidism or with an autonomously functioning thyroid nodule suggest that this additional risk be evaluated in such patients before the use of any contrast medium. Some agents such as ioversol are contraindicated in symptomatic hyperthyroidism.

Major

Radiopaque contrast agents (applies to Isovue-300) pheochromocytoma

Major Potential Hazard, Moderate plausibility.

Administration of radiopaque materials to patients known or suspected of having pheochromocytoma should be performed with extreme caution. If, in the opinion of the physician, the possible benefits of such procedures outweigh the considered risk, the procedures should be performed with the absolute minimum amount of injected radiopaque medium. The blood pressure should be assessed throughout the procedure and measures for treatment of a hypertensive crisis should be available.

Moderate

Contrast agents (applies to Isovue-300) sickle cell disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Sickle Cell Anemia

Some contrast agents have shown to promote the phenomenon of sickling (blood cell rupture) in individuals who are homozygous for sickle cell disease when administered intravenously or intra- arterially. Caution is advised.

Moderate

Intravascular contrast agents (applies to Isovue-300) multiple myeloma

Moderate Potential Hazard, Moderate plausibility.

A definite risk exists in the use of intravascular contrast agents in patients who are known to have multiple myeloma. In such cases, anuria has developed resulting in progressive uremia, renal failure and eventually death. Although neither the contrast agent nor dehydration has separately proved to be the cause of anuria in myeloma, it has been speculated that the combination of both may be causative factors. The risk in patients with myeloma is not a contraindication to the procedure; however, partial dehydration in the preparation of these patients for the examination is not recommended since this may predispose to precipitation of myeloma protein in the renal tubules. Myeloma, which occurs most commonly in persons over 40, should be considered before instituting intravascular administration of contrast agents.

Moderate

Iodinated contrast agents (applies to Isovue-300) myasthenia gravis

Moderate Potential Hazard, Moderate plausibility.

The administration of iodinated contrast media may aggravate the symptoms of myasthenia gravis. Caution is advised when using these agents in patients with this condition.

Moderate

Iodinated contrast media (applies to Isovue-300) asthma/allergies

Moderate Potential Hazard, Moderate plausibility.

Iodinated contrast media such as ioversol, can cause life-threatening or fatal hypersensitivity reactions including anaphylaxis and anaphylactic shock. Manifestations include respiratory arrest, laryngospasm, bronchospasm, angioedema, and shock. Most severe reactions develop shortly after the start of the injection (e.g. within 1 to 3 minutes), but delayed reactions may occur. There is an increased risk in patients with a history of a previous reaction to contrast agent, and known allergies (i.e., bronchial asthma, drug, or food allergies), and other hypersensitivities. Caution is advised on these patients. Premedication with antihistamines or corticosteroids to avoid or minimize possible allergic reactions may reduce both their incidence and severity.

Moderate

Iodinated contrast media (applies to Isovue-300) renal disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Kidney Transplant, Hypertension, Liver Disease, Congestive Heart Failure

In patients with advanced renal disease, iodinated contrast media should be used with caution, and only when the need for the examination dictates, since the excretion of the medium may be impaired. Patients with combined renal and hepatic disease, severe hypertension or congestive heart failure, and those with recent renal transplant may present an additional risk.

Moderate

Iopamidol (applies to Isovue-300) allergic reactions

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Asthma, Allergies

The possibility of a reaction, including serious, life-threatening, fatal, anaphylactoid or cardiovascular reactions, should always be considered when using iopamidol. Patients at increased risk include those with a history of a previous reaction to a contrast medium, patients with a known sensitivity to iodine per se, and patients with a known clinical hypersensitivity (bronchial asthma, hay fever, and food allergies). Caution and monitoring is advised. Competent personnel and emergency facilities should be available for at least 30 to 60 minutes since severe delayed reactions may occur.

Moderate

Iopamidol (applies to Isovue-300) congestive heart failure

Moderate Potential Hazard, Moderate plausibility.

After parenteral administration of a radiopaque agent such as iopamidol, competent personnel and emergency facilities should be available for at least 30 to 60 minutes since severe delayed reactions may occur. Caution should be exercised in hydrating patients with underlying conditions that may be worsened by fluid overload, such as congestive heart failure.

Moderate

Iopamidol (applies to Isovue-300) dehydration

Moderate Potential Hazard, Moderate plausibility.

When using iopamidol, preparatory dehydration is dangerous and may contribute to acute renal failure in patients with advanced vascular disease, diabetic patients, and in susceptible nondiabetic patients (often elderly with preexisting renal disease). Patients should be well hydrated prior to and following iopamidol administration.

Isovue-300 (iopamidol) drug interactions

There are 318 drug interactions with Isovue-300 (iopamidol)

Isovue-300 (iopamidol) alcohol/food interactions

There is 1 alcohol/food interaction with Isovue-300 (iopamidol)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.