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Droxia (hydroxyurea) Disease Interactions

There are 5 disease interactions with Droxia (hydroxyurea):

Major

Hydroxyurea (Includes Droxia) ↔ Myelosuppression

Severe Potential Hazard, Moderate plausibility

Applies to: Bleeding, Bone Marrow Depression/Low Blood Counts, Fever

The use of hydroxyurea is contraindicated in patients with marked myelosuppression. Hydroxyurea induces myelosuppression, primarily leukopenia. Thrombocytopenia and anemia occur less frequently. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Close clinical monitoring of hematopoietic function is recommended. Hydroxyurea should not be administered if the white blood cell count falls below 2500/mm3 and/or the platelet count falls below 100,000/mm3, or in the presence of severe anemia.

References

  1. "Product Information. Hydrea (hydroxyurea)." Bristol-Myers Squibb, Princeton, NJ.
Major

Hydroxyurea (Includes Droxia) ↔ Renal Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Renal Dysfunction

Hydroxyurea is primarily eliminated by the kidney. Approximately 80% of urea is excreted in the urine as unchanged drug or urea. Patients with marked renal impairment (CrCl < 60 mL/min or ESRD) may be at increased risk of toxicity associated with administration of hydroxyurea. Therapy with hydroxyurea should be administered cautiously to patients with compromised renal function.

References

  1. "Product Information. Hydrea (hydroxyurea)." Bristol-Myers Squibb, Princeton, NJ.
Moderate

Hydroxyurea (Includes Droxia) ↔ Hepatic Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

There are no data supporting specific guidance for hydroxyurea dosage adjustment in patients with hepatic impairment. Caution and close monitoring is advised in these patients.

Moderate

Hydroxyurea (Includes Droxia) ↔ Seizure Disorders

Moderate Potential Hazard, Low plausibility

Applies to: Seizures

Seizures have been noted very rarely during hydroxyurea therapy. Therapy with hydroxyurea should be administered cautiously in patients with seizure disorders.

References

  1. "Product Information. Hydrea (hydroxyurea)." Bristol-Myers Squibb, Princeton, NJ.
Moderate

Hydroxyurea (Includes Droxia) ↔ Neurologic Disorders

Minor Potential Hazard, Low plausibility

Applies to: Psychosis

Neurological symptoms such as disorientation or hallucinations have been reported very rarely during hydroxyurea therapy. Therapy with hydroxyurea should be administered cautiously to patients with or predisposed to neurological disorders.

References

  1. "Product Information. Hydrea (hydroxyurea)." Bristol-Myers Squibb, Princeton, NJ.

Droxia (hydroxyurea) drug Interactions

There are 183 drug interactions with Droxia (hydroxyurea)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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