Medications for Sickle Cell Disease
Other names: Anemia, Sickle Cell; Hb SS; Hemoglobin SS disease; SCD; Sickle Cell Anemia
Sickle cell disease is a group of inherited red blood cell red blood disorders affecting hemoglobin, the protein that carries oxygen through the body.
Sickle cell disease is caused by a mutation in the hemoglobin-beta gene.
Healthy red blood cells with normal hemoglobin (hemoglobin-A) are disc shaped and glide smoothly through the blood vessels. In people with sickle cell disease, the red blood cells contain abnormal hemoglobin (hemoglobin-S) which causes them to become stiff and "sickle" shaped. The sickle cells accumulate in the blood vessels causing blockages, pain, and damage to organs and tissue.
Symptoms of sickle cell disease include anemia resulting from the rapid destruction of the sickle cells in the body, periodic episodes of extreme pain (pain crises), swelling of the hands and feet, frequent infections, delayed growth or puberty, and vision problems. Complications include stroke, acute chest syndrome, pulmonary hypertension, organ damage, splenic sequestration, blindness, leg ulcers, gallstones, priapism, deep vein thrombosis, and high blood pressure and blood clots during pregnancy.
Currently the only cure for sickle cell disease is bone marrow transplantation, but there are new gene therapies in development that work to correct the defective gene so as to stimulate production of normal hemoglobin.
Drugs used to treat Sickle Cell Disease
The following list of medications are in some way related to or used in the treatment of this condition.
|Drug name||Rating||Reviews||Activity ?||Rx/OTC||Pregnancy||CSA||Alcohol|
|hydroxyurea||7.8||13 reviews for hydroxyurea to treat Sickle Cell Disease||Rx|
|vitamin e||0.0||1 review for vitamin e to treat Sickle Cell Disease||Rx/OTC|
|Hydrea||6.5||4 reviews for Hydrea to treat Sickle Cell Disease||Rx|
|Oxbryta||6.5||7 reviews for Oxbryta to treat Sickle Cell Disease||Rx|
|Aquasol E||Rate||Add review||Rx/OTC|
|Alpha E||Rate||Add review||Rx/OTC|
|E-400 Clear||Rate||Add review||Rx/OTC|
|E Pherol||Rate||Add review||Rx/OTC|
|voxelotor||6.7||8 reviews for voxelotor to treat Sickle Cell Disease||Rx|
|Aqua Gem-E||Rate||Add review||Rx/OTC|
Frequently asked questions
- How does Endari work to treat sickle cell disease?
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- What type of drug is Adakveo and how does it work?
- How is Adakveo administered?
Learn more about Sickle Cell Disease
Symptoms and treatments
|Rating||For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).|
|Activity||Activity is based on recent site visitor activity relative to other medications in the list.|
|Rx/OTC||Prescription or Over-the-counter.|
|Off-label||This medication may not be approved by the FDA for the treatment of this condition.|
|EUA||An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.|
|Expanded Access||Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.|
|A||Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).|
|B||Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.|
|C||Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.|
|D||There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.|
|X||Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.|
|N||FDA has not classified the drug.|
|Controlled Substances Act (CSA) Schedule|
|M||The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.|
|U||CSA Schedule is unknown.|
|N||Is not subject to the Controlled Substances Act.|
|1||Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.|
|2||Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.|
|3||Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.|
|4||Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.|
|5||Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.|
|X||Interacts with Alcohol.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.