Hydroxy-Cobal Disease Interactions
There are 3 disease interactions with Hydroxy-Cobal (hydroxocobalamin).
Cyano-/hydroxocobalamin (vit B12) (applies to Hydroxy-Cobal) hypokalemia
Major Potential Hazard, High plausibility.
Hypokalemia (resulting in death) has occurred during vitamin B12 therapy as a result of increased red blood cell requirements during hematopoiesis. Clinical monitoring and correction of potassium levels prior to and during vitamin B12 therapy is necessary.
References (2)
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- (2001) "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc
Cyano-/hydroxocobalamin (vit B12) (applies to Hydroxy-Cobal) optic nerve
Major Potential Hazard, High plausibility. Applicable conditions: Leber's Disease
The use of cyanocobalamin is contraindicated in patients with Leber's disease (hereditary optic nerve atrophy). Cyanocobalamin has induced severe and rapid optic nerve atrophy in patient's with early Leber's disease.
References (2)
- "Product Information. Nascobol (cyanocobalamin nasal)." Schwarz Pharma, Mequon, WI.
- (2001) "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc
Cyano-/hydroxocobalamin (vit B12) (applies to Hydroxy-Cobal) malabsorption
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Malabsorption Syndrome
Absorption of vitamin B12 is decreased in malabsorption syndromes and in pernicious anemia without coadministration of intrinsic factor (IF). Cyanocobalamin is rapidly absorbed following IM or subcutaneous injections. Hydroxocobalamin (cyanocobalamin analog) functions the same a cyanocobalamin, but has induced antibody formation to the hydroxocobalamin-transcobalamin II complex. The use of cyanocobalamin may be preferred in patients with these conditions.
References (1)
- (2001) "Product Information. Hydro-Cobex (hydroxocobalamin)." Major Pharmaceuticals Inc
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Hydroxy-Cobal drug interactions
There are 7 drug interactions with Hydroxy-Cobal (hydroxocobalamin).
More about Hydroxy-Cobal (hydroxocobalamin)
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- Drug class: vitamins
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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