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Hydroxocobalamin Dosage

Applies to the following strength(s): 1000 mcg/mL ; 2.5 g ; 5 g

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Schilling Test

1000 mcg IM

Usual Adult Dose for Vitamin B12 Deficiency

Uncomplicated disease:
Initial dose: 30 mcg IM once daily for 5 to 10 days, or 100 mcg IM once daily for one week, followed by 100 mcg IM every other day for 2 weeks.
Maintenance dose: 100 to 200 mcg IM once a month

Complicated disease:
Initial dose: 1000 mcg IM once with folic acid 15 mg, followed by 100 mcg once daily with folic acid 5 mg daily for 1 week
Maintenance dose: 100 to 200 mcg IM once a month

Usual Adult Dose for Cyanide Poisoning

5 g, intravenously, as a single infusion over 15 minutes. May repeat a second 5 g dose, depending on the severity of poisoning and clinical response, for a maximum cumulative dose of 10 g.

Usual Pediatric Dose for Schilling Test

1000 mcg IM

Usual Pediatric Dose for Transcobalamin II Deficiency

Neonates: 1000 mcg IM twice a week

Usual Pediatric Dose for Vitamin B12 Deficiency

Uncomplicated disease:
Initial dose: 100 mcg IM daily for 10 to 15 days for a total dose of 1 to 5 mg, then maintenance of 60 mcg/month;

or 30 to 50 mcg/day for at least two weeks for a total dose of 1 to 5 mg, then maintenance of 100 mcg/month.

Renal Dose Adjustments

The dosage interval may need to be adjusted in patients with renal dysfunction.

Liver Dose Adjustments

The dosage interval may need to be adjusted in patients with liver disease.

Precautions

Hydroxocobalamin is not for intravenous administration.

Dialysis

Data not available

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