Hydroxy-Cobal Side Effects
Generic name: hydroxocobalamin
Medically reviewed by Drugs.com. Last updated on Sep 3, 2022.
Note: This document contains side effect information about hydroxocobalamin. Some dosage forms listed on this page may not apply to the brand name Hydroxy-Cobal.
Applies to hydroxocobalamin: intravenous powder for solution.
Serious side effects of Hydroxy-Cobal
Along with its needed effects, hydroxocobalamin (the active ingredient contained in Hydroxy-Cobal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking hydroxocobalamin:
- Blurred vision
- pounding in the ears
- redness of the skin
- slow or fast heartbeat
Incidence not known
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- difficult or labored breathing
- difficulty with swallowing
- feeling of warmth
- hives or welts, itching, or skin rash
- large, hive-like swelling on the , eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- redness of the face, neck, arms, and occasionally, upper chest
- sudden sweating
- tightness in the chest
- tingling of the hands or feet
- unusual tiredness or weakness
- unusual weight gain or loss
Other side effects of Hydroxy-Cobal
Some side effects of hydroxocobalamin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Acid or sour stomach
- being forgetful
- redness or swelling of the eyes
- stomach discomfort, upset, or pain
For Healthcare Professionals
Applies to hydroxocobalamin: compounding powder, injectable solution, intravenous powder for injection.
Very common (10% or more): Blood pressure increased (28% with 10 gram dose)
Frequency not reported: Increased blood pressure (particularly diastolic), hot flush, ventricular extrasystoles, electrocardiogram repolarization abnormality, heart rate increased[Ref]
Very common (10% or more): Nausea (11% with 10 gram dose)
Very common (10% or more): Erythema (100% with 10 gram dose), rash (primarily acneiform) (44% with 10 gram dose)
Very common (10% or more): Chromaturia (red colored urine) (100% with 5 or 10 gram dose), oxalate crystals in urine (61% with 5 gram dose)
Postmarketing reports: Urine calcium oxalate crystals[Ref]
Very common (10% or more): Lymphocyte count decreased (17% with 10 gram dose)[Ref]
Very common (10% or more): Infusion site reaction (39% with 10 gram dose)[Ref]
Postmarketing reports: Acute renal failure with acute tubular necrosis, renal impairment[Ref]
Very common (10% or more): Headache (33% with 10 gram dose)
Frequency not reported: Memory impairment, dizziness[Ref]
Pleural effusion was seen in known/suspected cyanide poisoning patients.[Ref]
Frequency not reported: Allergic reaction[Ref]
Frequency not reported: Swelling, irritation, redness[Ref]
Frequency not reported: Restlessness[Ref]
More about Hydroxy-Cobal (hydroxocobalamin)
Related treatment guides
1. "Product Information. Cyanokit (hydroxocobalamin)." Meridian Medical Technologies Inc (2011):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.