Folic acid/heme iron polypeptide Disease Interactions
There are 2 disease interactions with folic acid/heme iron polypeptide.
Ferrous salts (applies to folic acid/heme iron polypeptide) hemoglobin abnormalities
Major Potential Hazard, Moderate plausibility. Applicable conditions: Blood Transfusion, Hemoglobinopathy
There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.
References (2)
- "Product Information. Infed (iron dextran)." Schein Pharmaceuticals Inc
- (2001) "Product Information. Venofer (iron sucrose)." American Regent Laboratories Inc
Folic acid (applies to folic acid/heme iron polypeptide) anemia
Major Potential Hazard, High plausibility. Applicable conditions: Anemia of Unspecified Nutritional Deficiency
The use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.
References (3)
- Butterworth CE Jr, Tamura T (1989) "Folic acid safety and toxicity: a brief review." Am J Clin Nutr, 50, p. 353-8
- Katz M (1973) "Potential danger of self-medication with folic acid." N Engl J Med, 289, p. 1095
- "Product Information. Renal Multivitamin Formula Rx (folic acid)." Vitaline Corporation, Ashland, OR.
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Folic acid/heme iron polypeptide drug interactions
There are 113 drug interactions with folic acid/heme iron polypeptide.
Folic acid/heme iron polypeptide alcohol/food interactions
There is 1 alcohol/food interaction with folic acid/heme iron polypeptide.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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