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Ferrous fumarate/folic acid/iron polysaccharide Disease Interactions

There are 4 disease interactions with ferrous fumarate/folic acid/iron polysaccharide.

Major

Ferrous salts (applies to ferrous fumarate/folic acid/iron polysaccharide) hemoglobin abnormalities

Major Potential Hazard, High plausibility. Applicable conditions: Blood Transfusion, Hemoglobinopathy, Hemoglobinopathy, Blood Transfusion

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.

References

  1. "Product Information. Infed (iron dextran)." Schein Pharmaceuticals Inc
  2. (2001) "Product Information. Venofer (iron sucrose)." American Regent Laboratories Inc
Major

Folic acid (applies to ferrous fumarate/folic acid/iron polysaccharide) anemia

Major Potential Hazard, High plausibility. Applicable conditions: Anemia of Unspecified Nutritional Deficiency

The use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.

References

  1. Butterworth CE Jr, Tamura T (1989) "Folic acid safety and toxicity: a brief review." Am J Clin Nutr, 50, p. 353-8
  2. Katz M (1973) "Potential danger of self-medication with folic acid." N Engl J Med, 289, p. 1095
  3. "Product Information. Renal Multivitamin Formula Rx (folic acid)." Vitaline Corporation, Ashland, OR.
Moderate

Ferrous salts (applies to ferrous fumarate/folic acid/iron polysaccharide) achlorhydria

Moderate Potential Hazard, Moderate plausibility.

Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.

References

  1. "Product Information. Feosol (ferrous sulfate)." SmithKline Beecham
  2. (2016) "Product Information. Ferrous Gluconate (ferrous gluconate)." Paddock Laboratories Inc
Moderate

Ferrous salts (applies to ferrous fumarate/folic acid/iron polysaccharide) gastrointestinal irritation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Peptic Ulcer, Colitis/Enteritis (Noninfectious), Peptic Ulcer, Colitis/Enteritis (Noninfectious)

Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.

References

  1. "Product Information. Feosol (ferrous sulfate)." SmithKline Beecham
  2. (2016) "Product Information. Ferrous Gluconate (ferrous gluconate)." Paddock Laboratories Inc

Ferrous fumarate/folic acid/iron polysaccharide drug interactions

There are 120 drug interactions with ferrous fumarate/folic acid/iron polysaccharide.

Ferrous fumarate/folic acid/iron polysaccharide alcohol/food interactions

There are 3 alcohol/food interactions with ferrous fumarate/folic acid/iron polysaccharide.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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