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Equi-Cyte F (ferrous fumarate / folic acid) Disease Interactions

There are 4 disease interactions with Equi-Cyte F (ferrous fumarate / folic acid):

Major

Ferrous Salts (Includes Equi-Cyte F) ↔ Hemoglobin Abnormalities

Severe Potential Hazard, High plausibility

Applies to: Hemoglobinopathy, Blood Transfusion

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.

References

  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.
Major

Folic Acid (Includes Equi-Cyte F) ↔ Anemia

Severe Potential Hazard, High plausibility

Applies to: Anemia of Unspecified Nutritional Deficiency

The use of folic acid is contraindicated in patients with undiagnosed anemia. Folic acid in dosages above 1 mg/day can obscure the diagnosis of pernicious anemia by alleviating the hematologic abnormalities while allowing the progression of neurologic complications. In addition, folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where vitamin B12 is deficient.

References

  1. Butterworth CE Jr, Tamura T "Folic acid safety and toxicity: a brief review." Am J Clin Nutr 50 (1989): 353-8
  2. Katz M "Potential danger of self-medication with folic acid." N Engl J Med 289 (1973): 1095
  3. "Product Information. Renal Multivitamin Formula Rx (folic acid)." Vitaline Corporation, Ashland, OR.
Moderate

Ferrous Salts (Includes Equi-Cyte F) ↔ Achlorhydria

Moderate Potential Hazard, Moderate plausibility

Applies to: Achlorhydria

Gastric acidity increases iron bioavailability by maintaining the ingested iron in a reduced form as ferrous ions, which are more readily absorbed than ferric ions. Therefore, when iron therapy is administered orally, higher dosages may be necessary for patients with decreased gastric acid production. Also, a liquid formulation is recommended in these patients because dissolution of the tablet coating depends on normal gastric acidity.

References

  1. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.
Moderate

Ferrous Salts (Includes Equi-Cyte F) ↔ Gastrointestinal Irritation

Moderate Potential Hazard, High plausibility

Applies to: Peptic Ulcer, Colitis/Enteritis (Noninfectious)

Iron can be irritating and damaging to gastrointestinal mucosa. Iron therapy should be administered cautiously in patients with peptic ulcer disease, enteritis, or ulcerative colitis.

References

  1. "Product Information. Feosol Tablets (ferrous sulfate)." SmithKline Beecham, Philadelphia, PA.

Equi-Cyte F (ferrous fumarate / folic acid) drug Interactions

There are 169 drug interactions with Equi-Cyte F (ferrous fumarate / folic acid)

Equi-Cyte F (ferrous fumarate / folic acid) alcohol/food Interactions

There is 1 alcohol/food interaction with Equi-Cyte F (ferrous fumarate / folic acid)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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