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Febuxostat Disease Interactions

There are 4 disease interactions with febuxostat:

Major

Antihyperuricemic Agents (Includes Febuxostat) ↔ Secondary Hyperuricemia

Severe Potential Hazard, Moderate plausibility

Applies to: Tumor Lysis Syndrome, Lesch-Nyhan Syndrome, Organ Transplant

No studies with febuxostat or lesinurad have been conducted in patients with secondary hyperuricemia (including organ transplant recipients). The use of these drugs is contraindicated in patients where the uric acid formation is greatly increased, such as patients with malignant disease, tumor lysis syndrome or Lesch-Nyhan syndrome.

Moderate

Antihyperuricemic Agents (Includes Febuxostat) ↔ Cv Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Cardiovascular Disease

Major adverse cardiovascular events (cardiovascular deaths, non- fatal myocardial infarctions and non- fatal strokes), were reported during clinical trials with some antihyperuricemic agents, such as febuxostat and lesinurad. Although a causal relationship has not been established, caution is advised when used in patients with cardiovascular disease. Monitoring for signs or symptoms of myocardial infarction or stroke is recommended.

Moderate

Febuxostat (Includes Febuxostat) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

There are insufficient data on the use of febuxostat in patients with severe renal impairment (ClCr less than 30 mL/min), therefore caution should be exercised on these patients. No dose adjustment is needed in patients with mild or moderate renal impairment.

Moderate

Febuxostat/Lesinurad (Includes Febuxostat) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

No studies have been conducted in patients with severe hepatic impairment (Child-Pugh Class C), therefore caution should be exercised if using febuxostat or lesinurad on these patients. No dose adjustment is necessary in patients with mild or moderate hepatic impairment.

febuxostat drug Interactions

There are 56 drug interactions with febuxostat

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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