Drizalma Sprinkle Disease Interactions
There are 10 disease interactions with Drizalma Sprinkle (duloxetine).
- Liver disease
- Renal disease
- Depression
- Diabetes
- Glaucoma
- Hypertension
- Hyponatremia
- Mania
- Seizures
- Urinary tract obstruction
Duloxetine (applies to Drizalma Sprinkle) liver disease
Major Potential Hazard, Moderate plausibility.
Postmarketing studies have reported that duloxetine and some other SNRIs like milnacipran may aggravate preexisting liver disease. The use of duloxetine delayed-release and milnacipran should be avoided in patients with chronic liver disease or cirrhosis.
Duloxetine (applies to Drizalma Sprinkle) renal disease
Major Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The use of duloxetine should be avoided in patients with severe renal impairment (GFR <30 mL/min).
SNRI antidepressants (applies to Drizalma Sprinkle) depression
Major Potential Hazard, Moderate plausibility. Applicable conditions: Bipolar Disorder
Adult and pediatric patients with depression and other psychiatric disorders may experience worsening of their symptoms and may have the emergence of suicidal thoughts and behavior. Patients should be monitored appropriately and observed closely for worsening of their symptoms, suicidality or changes in their behavior, especially during the first few months of treatment, and at times of dose changes. Discontinuing the medication should be considered if symptoms are persistently worse, or abrupt in onset. It may be prudent to refrain from dispensing large quantities of medication to these patients.
Duloxetine (applies to Drizalma Sprinkle) diabetes
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus
In clinical trials, treatment with duloxetine delayed-release worsened the glycemic control in some patients with diabetes. Caution should be used when using duloxetine in diabetic patients and their glycemic levels should be checked regularly.
SNRI antidepressants (applies to Drizalma Sprinkle) glaucoma
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma (Narrow Angle)
SNRI antidepressants cause pupillary dilation that may trigger an angle closure attack in patients with anatomically narrow angle without iridectomy.
SNRI antidepressants (applies to Drizalma Sprinkle) hypertension
Moderate Potential Hazard, Moderate plausibility.
Selective serotonin and norepinephrine reuptake inhibitor antidepressants (SNRIs) have been associated with sustained increases in blood pressure. Therapy with SNRI antidepressants should be administered cautiously in patients with preexisting hypertension. Blood pressure should be assessed prior to initiating treatment and monitored regularly. The dose should be reduced or discontinued if necessary.
SNRI antidepressants (applies to Drizalma Sprinkle) hyponatremia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Dehydration
Treatment with SNRI antidepressants can cause hyponatremia. Caution should be used when treating patients with hyponatremia or at greater risk of hyponatremia such as the elderly, patients taking diuretics or who are volume depleted.
SNRI antidepressants (applies to Drizalma Sprinkle) mania
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bipolar Disorder
Therapy with SNRI antidepressants can cause activation of mania and hypomania and should be used with caution in patients with personal or family history of mania, hypomania, bipolar disorder, and other mood disorders.
SNRI antidepressants (applies to Drizalma Sprinkle) seizures
Moderate Potential Hazard, Moderate plausibility.
SNRI antidepressants may trigger seizures and should be administered with caution in patients with a seizure disorder.
SNRI antidepressants (applies to Drizalma Sprinkle) urinary tract obstruction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Urinary Tract Infection
SNRI antidepressants have a noradrenergic effect and can affect urethral resistance. Caution should be used in patients with a history of dysuria, prostatic hypertrophy, prostatitis, and other lower urinary tract obstructive disorders.
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Drizalma Sprinkle drug interactions
There are 633 drug interactions with Drizalma Sprinkle (duloxetine).
Drizalma Sprinkle alcohol/food interactions
There are 2 alcohol/food interactions with Drizalma Sprinkle (duloxetine).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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