Desmopressin Disease Interactions
There are 4 disease interactions with desmopressin.
Desmopressin (applies to desmopressin) renal dysfunction
Major Potential Hazard, High plausibility.
The use of desmopressin is contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50 mL/min).
References
- (2001) "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer
- (2001) "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals
Vasopressin/desmopressin (applies to desmopressin) fluid overload/hyponatremia
Major Potential Hazard, High plausibility. Applicable conditions: Fluid Retention, Seizures, Congestive Heart Failure, Migraine, Asthma
Water intoxication and hyponatremia may occur during therapy with vasopressin or desmopressin due to their antidiuretic action. Patients are most likely to experience this problem if their fluid intake is excessive or if they do not require antidiuresis, such as when they are administered these agents for their hemostatic effects. Fluid intake should be adjusted carefully to avoid overhydration, particularly in children, elderly, and patients with conditions that may be exacerbated by fluid retention, including epilepsy, migraine, asthma, and heart failure. Patients should be monitored for signs of water intoxication (e.g., listlessness, drowsiness, and headaches), which may rarely progress to seizures and coma. The use of desmopressin is contraindicated in patients with hyponatremia or a history of hyponatremia.
References
- (2001) "Product Information. Pitressin (vasopressin)." Parke-Davis
- (2001) "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer
- (2001) "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals
- Lin TW, Kuo YS (1996) "Acute pulmonary oedema following administration of vasopressin for control of massive GI tract haemorrhage in a major burn patient." Burns, 22, p. 73-5
- Tulandi T, Beique F, Kimia M (1996) "Pulmonary edema: a complication of local injection of vasopressin at laparoscopy." Fertil Steril, 66, p. 478-80
- Robson WLM (1996) "Water intoxication in patients treated with desmopressin." Pharmacotherapy, 16, p. 969-70
- Williford SL (1996) "Water intoxication in patients treated with desmopressin - reply." Pharmacotherapy, 16, p. 970
- Robson WLM, Norgaard JP, Leung AKC (1996) "Hyponatremia in patients with nocturnal enuresis treated with DDAVP." Eur J Pediatr, 155, p. 959-62
Desmopressin (applies to desmopressin) thrombotic events
Moderate Potential Hazard, Low plausibility. Applicable conditions: Thrombotic/Thromboembolic Disorder, History - Thrombotic/Thromboembolic Disorder
Rare cases of thrombotic events (thrombosis, acute cerebrovascular thrombosis, and acute myocardial infarction) have been reported following desmopressin injection in patients predisposed to thrombus formation. Although a causal relationship has not been established, therapy with desmopressin should be administered cautiously in patients with a current or past history of thrombotic or thromboembolic disorders.
References
- (2001) "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer
- (2001) "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals
- Vermylen J, Peerlinck K (1995) "Fatal complication of desmopressin." Lancet, 346, p. 447
Desmopressin (applies to desmopressin) vascular disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Ischemic Heart Disease, Hypertension
The use of desmopressin, primarily in parenteral administration and/or in large doses, has been infrequently associated with changes in blood pressure, causing either slight elevations or transient decreases with a compensatory increase in heart rate. Therapy with desmopressin, regardless of route of administration, should be administered cautiously in patients with coronary artery insufficiency and/or hypertensive cardiovascular disease.
References
- (2001) "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer
- (2001) "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals
Desmopressin drug interactions
There are 122 drug interactions with desmopressin.
Desmopressin alcohol/food interactions
There are 2 alcohol/food interactions with desmopressin.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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