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Dapsone Disease Interactions

There are 2 disease interactions with dapsone:

Major

Dapsone (applies to dapsone) bone marrow suppression

Major Potential Hazard, High plausibility. Applicable conditions: G-6-PD Deficiency, Bone Marrow Depression/Low Blood Counts

The use of dapsone has been associated with development of agranulocytosis, aplastic anemia, and other blood dyscrasias. Blood dyscrasias are more likely to occur in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Patients should be instructed to report any signs of infection (sore throat, fever, local infection, bleeding, or symptoms of anemia). Monitoring for hematologic abnormalities is recommended.

References

  1. Cockburn EM, Wood SM, Waller PC, Bleehen SS "Dapsone-induced agranulocytosis: spontaneous reporting data." Br J Dermatol 128 (1993): 702-3
  2. Duhra P, Charles-Holmes R "Linear IgA disease with haemorrhagic pompholyx and dapsone-induced neutropenia." Br J Dermatol 125 (1991): 172-4
  3. McConkey B "Adverse reactions to dapsone." Lancet 2 (1981): 525
  4. Cook I, Kish M "Haematological safety of long-term malarial prophylaxis with dapsone-pyrimethamine." Med J Aust 143 (1985): 139-41
  5. Hornsten P, Keisu M, Wiholm B "The incidence of agranulocytosis during treatment of dermatitis herpetiformis with dapsone as reported in Sweden, 1972 through 1988." Arch Dermatol 126 (1990): 919-22
  6. Meyerson MA, Cohen PR "Dapsone-induced aplastic anemia in a woman with bullous systemic lupus erythematosus." Mayo Clin Proc 69 (1994): 1159-62
  7. Laing A "Unusual reaction to intramuscular sulfone in two leprosy patients in malaysia." Int J Lepr 48 (1980): 70
  8. Potter M, Yates P, Slade R, Kennedy C "Agranulocytosis caused by dapsone therapy for granuloma annulare." J Am Acad Dermatol 20 (1989): 87-8
  9. Raizman MB, Fay AM, Weiss JS "Dapsone induced neutropenia in patients treated for ocular cicatricial pemphigoid." Ophthalmology 101 (1994): 1805-7
  10. Woodbury GR, Jr Fried W, Ertle JO, Malkinson FD "Dapsone-associated agranulocytosis and severe anemia in a patient with leukocytoclastic vasculitis." J Am Acad Dermatol 28 (1993): 781-3
  11. Kraus A, Jakez J, Palacios A "Dapsone induced sulfone syndrome and systemic lupus exacerbation." J Rheumatol 19 (1992): 178-9
View all 11 references
Moderate

Dapsone (applies to dapsone) liver disease

Moderate Potential Hazard, Moderate plausibility.

The use of dapsone has been associated with the development of hyperbilirubinemia. Patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are more likely to develop hyperbilirubinemia. Monitoring liver function is recommended and discontinuation of the drug may be necessary.

References

  1. May DG, Arns PA, Richards WO, et al "The disposition of dapsone in cirrhosis." Clin Pharmacol Ther 51 (1992): 689-700
  2. Mills J, Leoung G, Ileana M, Hopewell PC, Hughes WT, Wofsy C "Dapsone treatment of pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome." Antimicrob Agents Chemother 32 (1988): 1057-60
  3. Fleming CM, Branch RA, Wilkinson GR, Guengerich FP "Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4." Mol Pharmacol 41 (1992): 975-80
  4. "Product Information. Dapsone USP (dapsone)." Jacobus Pharmaceutical Company, Princeton, NJ.
  5. Beumont MG, Graziani A, Ubel PA, Macgregor RR "Safety of dapsone as pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected patients with allergy to trimethoprim/sulfamethoxazole." Am J Med 100 (1996): 611-6
View all 5 references

Dapsone drug interactions

There are 190 drug interactions with dapsone

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.