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Orgaran Disease Interactions

There are 7 disease interactions with Orgaran (danaparoid).

Major

Anticoagulants (applies to Orgaran) hemophilia

Major Potential Hazard, High plausibility. Applicable conditions: Coagulation Defect

Anticoagulants should be given with extreme caution to patients with hemophilia or other congenital or acquired bleeding tendencies. The risk of hemorrhage may be increased in these patients.

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Major

Anticoagulants (applies to Orgaran) liver disease

Major Potential Hazard, Low plausibility.

Anticoagulants should be given with extreme caution to patients at increased risk for hemorrhage, including patients who have severe liver disease with impaired hemostasis.

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Major

Anticoagulants (applies to Orgaran) peptic ulcer disease

Major Potential Hazard, High plausibility. Applicable conditions: Bleeding

Anticoagulants are contraindicated in patients with active major bleeding or those patients at risk for hemorrhage. Hemorrhage due to heparin derivatives may be treated with protamine sulfate 1%. However, protamine sulfate may not completely neutralize the anti- Factor Xa activity.

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Major

Anticoagulants (applies to Orgaran) retinopathy

Major Potential Hazard, Moderate plausibility. Applicable conditions: Diabetic Retinopathy, Hypertensive Retinopathy

The use of anticoagulants may increase the risk of bleeding in patients with hypertensive or diabetic retinopathy. Therapy with anticoagulants should be administered with extreme caution in such patients.

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Major

Anticoagulants (applies to Orgaran) subacute bacterial endocarditis

Major Potential Hazard, High plausibility. Applicable conditions: Infectious Endocarditis

Anticoagulants should be given with extreme caution to patients with subacute bacterial endocarditis. The risk of hemorrhage may be increased in these patients.

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Moderate

Anticoagulants (applies to Orgaran) hypertension

Moderate Potential Hazard, Moderate plausibility.

Anticoagulants should be used with extreme caution in patients at increased risk for hemorrhage, including those patients with severe hypertension.

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Moderate

Anticoagulants (applies to Orgaran) kidney disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Anticoagulants should be given with extreme caution to patients with severe kidney dysfunction. Altered coagulation may increase the risk of bleeding in these patients. If an anticoagulant is administered, these patients should be monitored closely for signs of bleeding.

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Orgaran drug interactions

There are 176 drug interactions with Orgaran (danaparoid).

Orgaran alcohol/food interactions

There is 1 alcohol/food interaction with Orgaran (danaparoid).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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