Dacomitinib Disease Interactions
There are 2 disease interactions with dacomitinib.
Dacomitinib (applies to dacomitinib) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The recommended dose of dacomitinib has not been established for patients with severe renal impairment (CrCl <30 mL/min). Caution is advised if used in these patients. No dose adjustment is recommended for patients with mild or moderate renal impairment.
Dacomitinib (applies to dacomitinib) severe hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The recommended dose of dacomitinib has not been established for patients with severe hepatic impairment (total bilirubin > 3 to 10 × ULN and any AST). Caution is advised if used in these patients. No dose adjustment is recommended in patients with mild or moderate hepatic impairment.
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Dacomitinib drug interactions
There are 111 drug interactions with dacomitinib.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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