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Tridate Disease Interactions

There are 5 disease interactions with Tridate (bisacodyl / magnesium citrate).

Major

Laxatives (applies to Tridate) inflammatory bowel disease

Major Potential Hazard, Moderate plausibility.

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

References (6)
  1. (2001) "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
  4. (2001) "Product Information. Neoloid (castor oil)." Paddock Laboratories Inc
  5. (2022) "Product Information. SenoSol-X (senna)." Apothecon Inc
  6. (2010) "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories
Major

Laxatives (applies to Tridate) intestinal obstruction disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction, Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

References (8)
  1. (2001) "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
  4. (2001) "Product Information. Fleet Mineral Oil Enema (mineral oil)." Fleet
  5. (2001) "Product Information. Citrucel (methylcellulose)." SmithKline Beecham
  6. (2001) "Product Information. Fleet Babylax (glycerin)." Alcon Laboratories Inc
  7. (2022) "Product Information. SenoSol-X (senna)." Apothecon Inc
  8. (2010) "Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates)." Braintree Laboratories
Major

Magnesium salts (applies to Tridate) renal dysfunction

Major Potential Hazard, High plausibility.

Magnesium is eliminated by the kidney. The serum concentration of magnesium is increased in patients with renal impairment. Magnesium toxicity includes CNS depression, muscular paralysis, respiratory depression, hypotension and prolonged cardiac conduction time. Disappearance of the patellar reflex is a useful clinical sign of magnesium intoxication. Therapy with magnesium should be administered cautiously and dosages should be modified in patients with compromised renal function. Clinical monitoring of serum magnesium levels is recommended.

References (5)
  1. (2001) "Product Information. Mag-Ox 400 (magnesium oxide)." Blaine Company Inc.
  2. (2001) "Product Information. Uro-Mag (magnesium oxide)." Blaine Company Inc.
  3. (2001) "Product Information. Slow-Mag (magnesium chloride)." Searle
  4. (2001) "Product Information. Magonate (magnesium gluconate)." Fleming and Company
  5. (2001) "Product Information. Losospan (magaldrate)." Whitehall-Robbins
Major

Stimulant laxatives (applies to Tridate) acute surgical abdomen

Major Potential Hazard, High plausibility. Applicable conditions: Appendicitis

The use of stimulant laxatives is contraindicated in patients with or who may have acute surgical abdomen or appendicitis. These patients may be candidates for emergency surgery. Stimulant laxatives should also not be administered to patients with abdominal pain, particularly if the cause has not been determined.

References (4)
  1. (2001) "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet
  3. "Product Information. Kondremul Plain (mineral oil)." Bristol-Myers Squibb
  4. (2022) "Product Information. SenoSol-X (senna)." Apothecon Inc
Major

Stimulant laxatives (applies to Tridate) rectal bleeding

Major Potential Hazard, Moderate plausibility.

The use of stimulant laxatives is contraindicated in patients with anal or rectal fissures. These preparations may cause irritation, burning sensation, and proctitis.

References (2)
  1. (2001) "Product Information. Dulcolax (bisacodyl)." Ciba Self-Medication Inc
  2. "Product Information. Fleet Bisacodyl (bisacodyl)." Fleet

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Tridate drug interactions

There are 282 drug interactions with Tridate (bisacodyl / magnesium citrate).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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