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Cough-X Cough Relief (benzocaine / dextromethorphan) Disease Interactions

There are 2 disease interactions with Cough-X Cough Relief (benzocaine / dextromethorphan):

Moderate

Antitussives (applies to Cough-X Cough Relief) psychiatric conditions

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Depression, Psychosis, Parkinsonism

Caution should be used when prescribing antitussives such as dextromethorphan and benzonatate in patients with psychiatric or emotional conditions. Isolated instances of bizarre behavior, including mental confusion and visual hallucinations have been reported in patients taking antitussives, specially when combined with other prescribed drugs such as monoamine oxidase inhibitors.

Moderate

Benzocaine (applies to Cough-X Cough Relief) methemoglobinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.

References

  1. "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health, Summit, NJ.
  2. "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals, Rochester, NY.

Cough-X Cough Relief (benzocaine / dextromethorphan) drug interactions

There are 315 drug interactions with Cough-X Cough Relief (benzocaine / dextromethorphan)

Cough-X Cough Relief (benzocaine / dextromethorphan) alcohol/food interactions

There is 1 alcohol/food interaction with Cough-X Cough Relief (benzocaine / dextromethorphan)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.