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Neosporin Disease Interactions

There are 2 disease interactions with Neosporin (bacitracin / neomycin / polymyxin b topical).


Neomycin (otic) (applies to Neosporin) perforated tympanic membrane

Major Potential Hazard, High plausibility.

Like other aminoglycosides, neomycin is potentially ototoxic, both to vestibular and to auditory functions. Therapy with neomycin otic preparations should be administered cautiously in patients with chronic otitis media or a perforated tympanic membrane. The risk of ototoxicity may be increased if medication enters the middle ear.


  1. "Product Information. Mycifradin (neomycin)." Emerson Laboratories PROD (2001):

Topical aminoglycosides (applies to Neosporin) burns

Moderate Potential Hazard, High plausibility. Applicable conditions: Burns - External

Topical aminoglycosides should not be used on serious burns. When applied locally, aminoglycosides are generally not absorbed to a significant extent through intact skin but readily absorbed through denuded, burned, or granulating skin. Systemic adverse effects of aminoglycosides include nephrotoxicity and ototoxicity to vestibular and auditory functions. In general, topical aminoglycosides should not be used on large areas of the body or for more than 7 days without medical supervision.


  1. "Product Information. Myciguent (neomycin topical)." Pharmacia and Upjohn PROD (2001):

Neosporin drug interactions

There are 21 drug interactions with Neosporin (bacitracin / neomycin / polymyxin b topical).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.