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Malarone Pediatric (atovaquone / proguanil) Disease Interactions

There are 2 disease interactions with Malarone Pediatric (atovaquone / proguanil):

Moderate

Atovaquone (Includes Malarone Pediatric) ↔ Gastrointestinal Absorption

Moderate Potential Hazard, High plausibility

Applies to: Anorexia/Feeding Problems, Malabsorption Syndrome, Diarrhea

Oral bioavailability of atovaquone is limited under fasting conditions, but is increased approximately two-fold when administered with food. Patients with gastrointestinal disorders or eating difficulties may be more likely to have impaired absorption and, consequently, subtherapeutic levels of the drug. Alternative parenteral treatment should be considered for patients unable to achieve adequate plasma concentrations of atovaquone with oral administration.

References

  1. Rolan PE, Mercer AJ, Weatherley BC, Holdich T, Ridout G, Meire H "Investigation of the factors responsible for a food-induced increase in absorption of a novel antiprotozoal drug 566C80." Br J Clin Pharmacol 33 (1992): p534-5
  2. "Product Information. Mepron (atovaquone)." Glaxo Wellcome, Research Triangle Park, NC.
Moderate

Atovaquone (Includes Malarone Pediatric) ↔ Liver Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Atovaquone may cause elevated liver function tests. In clinical trials, elevated serum alkaline phosphatase concentrations (> 2.5 times the upper limit of normal, or ULN) were reported in approximately 8% of patients, and elevations in serum ALT and AST (> 5 times ULN) were reported in 6% and 4% of patients, respectively. Increases in serum bilirubin has occurred rarely. Atovaquone also may undergo limited metabolism by the liver. Therapy with atovaquone should be administered cautiously in patients with severe hepatic impairment. Liver function tests should be performed periodically, and therapy withdrawn if significant elevations develop.

References

  1. "Product Information. Mepron (atovaquone)." Glaxo Wellcome, Research Triangle Park, NC.

Malarone Pediatric (atovaquone / proguanil) drug Interactions

There are 111 drug interactions with Malarone Pediatric (atovaquone / proguanil)

Malarone Pediatric (atovaquone / proguanil) alcohol/food Interactions

There is 1 alcohol/food interaction with Malarone Pediatric (atovaquone / proguanil)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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