Coartem (artemether / lumefantrine) Disease Interactions
There are 2 disease interactions with Coartem (artemether / lumefantrine):
Antimalarial agents (applies to Coartem) QT prolongation
Major Potential Hazard, Moderate plausibility. Applicable conditions: Magnesium Imbalance, Hypokalemia, Arrhythmias
The use of certain antimalarial agents is contraindicated in patients with known prolongation of QT interval as they can develop fatal arrhythmias. It should also be avoided in patients with clinical conditions known to prolong the QT interval, such as a congenital prolongation of the QT interval or sudden death, uncorrected hypokalemia or hypomagnesemia, bradycardia, and certain cardiac conditions. Caution is advised in patients taking other medications that can prolong the QT interval.
- "Product Information. Quinine (quinine)." Zenith Goldline Pharmaceuticals, Fort Lauderdale, FL.
Artemether (applies to Coartem) hepato/renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease
The pharmacokinetics of artemether have not been studied in patients with either hepatic or renal impairment. Additionally, the efficacy and safety of the drug has not been studied in patients with severe hepatic and/or renal impairment. No dose adjustment is recommended for patients with renal impairment as there is no or insignificant renal excretion of lumefantrine, artemether and dihydroartemisinin (DHA), an active antimalarial metabolite of artemether. No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. Caution should be exercised when administering lumefantrine and artemether to patients with severe hepatic or renal impairment. Close monitoring is recommended.
Coartem (artemether / lumefantrine) drug interactions
There are 339 drug interactions with Coartem (artemether / lumefantrine)
Coartem (artemether / lumefantrine) alcohol/food interactions
There is 1 alcohol/food interaction with Coartem (artemether / lumefantrine)
More about Coartem (artemether / lumefantrine)
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- Drug class: antimalarial combinations
- FDA Approval History
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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