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Armodafinil Disease Interactions

There are 6 disease interactions with armodafinil:

Moderate

Armodafinil (Includes armodafinil) ↔ alcoholism

Moderate Potential Hazard, Moderate plausibility. Applies to: Alcoholism

Patients with excessive sleepiness, including those taking armodafinil, should be frequently reassessed for their degree of sleepiness and, if appropriate, advised to avoid driving or any other potentially dangerous activity. Patients should refrain from drinking alcohol while taking armodafinil as any drug affecting the central nervous system (CNS) may alter judgment, thinking or motor skills.

Moderate

Armodafinil (Includes armodafinil) ↔ cardiovascular dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Cardiovascular Disease, Valvular Heart Disease

Armodafinil may cause ECG changes, chest pain, or arrhythmia. Armodafinil should be used with caution in patients with cardiovascular complications. Armodafinil should not be used in patients with a history of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants. It is recommended to monitor heart rate and blood pressure during treatment with armodafinil. Caution should be exercised when prescribing armodafinil to patients with known cardiovascular disease.

Moderate

Armodafinil (Includes armodafinil) ↔ liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

In a study to determine the pharmacokinetics and metabolism of armodafinil in patients with cirrhosis, the oral clearance of armodafinil was decreased by about 60%, and the steady state concentration was doubled compared to healthy patients. The dosage of armodafinil should be reduced in patients with severe hepatic impairment. Close monitoring is recommended.

Moderate

Armodafinil (Includes armodafinil) ↔ psychiatric complications

Moderate Potential Hazard, Moderate plausibility. Applies to: Psychosis, Depression

Armodafinil may cause adverse psychiatric reactions. Caution should be exercised when using this agent in patients with a history of psychosis, depression, or mania. If psychiatric symptoms develop in association with armodafinil administration, consider discontinuing armodafinil. Close monitoring of psychiatric symptoms is recommended.

Moderate

CNS stimulants (Includes armodafinil) ↔ bipolar disorders

Moderate Potential Hazard, Moderate plausibility. Applies to: Bipolar Disorder

Central nervous system (CNS) stimulants may induce a mixed/manic episode in patients with bipolar disorder. Prior to initiating treatment, screen patients for risk factors for developing a manic episode (e.g., comorbid or history of depressive symptoms or a family history of suicide, bipolar disorder, and depression). Close monitoring is recommended when using these agents in patients with bipolar disorders.

Moderate

CNS stimulants (Includes armodafinil) ↔ psychotic disorders

Moderate Potential Hazard, Moderate plausibility. Applies to: Psychosis

Central nervous system (CNS) stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with a preexisting psychotic disorder. Close monitoring is recommended when using these agents in patients with psychotic disorders.

Armodafinil drug interactions

There are 397 drug interactions with armodafinil

Armodafinil alcohol/food interactions

There is 1 alcohol/food interaction with armodafinil

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.