Armodafinil Disease Interactions
There are 6 disease interactions with armodafinil:
- Cardiovascular dysfunction
- Liver dysfunction
- Psychiatric complications
- Bipolar disorders
- Psychotic disorders
Armodafinil (Includes armodafinil) ↔ alcoholism
Moderate Potential Hazard, Moderate plausibility. Applies to: Alcoholism
Patients with excessive sleepiness, including those taking armodafinil, should be frequently reassessed for their degree of sleepiness and, if appropriate, advised to avoid driving or any other potentially dangerous activity. Patients should refrain from drinking alcohol while taking armodafinil as any drug affecting the central nervous system (CNS) may alter judgment, thinking or motor skills.
Armodafinil (Includes armodafinil) ↔ cardiovascular dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Cardiovascular Disease, Valvular Heart Disease
Armodafinil may cause ECG changes, chest pain, or arrhythmia. Armodafinil should be used with caution in patients with cardiovascular complications. Armodafinil should not be used in patients with a history of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants. It is recommended to monitor heart rate and blood pressure during treatment with armodafinil. Caution should be exercised when prescribing armodafinil to patients with known cardiovascular disease.
Armodafinil (Includes armodafinil) ↔ liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease
In a study to determine the pharmacokinetics and metabolism of armodafinil in patients with cirrhosis, the oral clearance of armodafinil was decreased by about 60%, and the steady state concentration was doubled compared to healthy patients. The dosage of armodafinil should be reduced in patients with severe hepatic impairment. Close monitoring is recommended.
Armodafinil (Includes armodafinil) ↔ psychiatric complications
Moderate Potential Hazard, Moderate plausibility. Applies to: Psychosis, Depression
Armodafinil may cause adverse psychiatric reactions. Caution should be exercised when using this agent in patients with a history of psychosis, depression, or mania. If psychiatric symptoms develop in association with armodafinil administration, consider discontinuing armodafinil. Close monitoring of psychiatric symptoms is recommended.
CNS stimulants (Includes armodafinil) ↔ bipolar disorders
Moderate Potential Hazard, Moderate plausibility. Applies to: Bipolar Disorder
Central nervous system (CNS) stimulants may induce a mixed/manic episode in patients with bipolar disorder. Prior to initiating treatment, screen patients for risk factors for developing a manic episode (e.g., comorbid or history of depressive symptoms or a family history of suicide, bipolar disorder, and depression). Close monitoring is recommended when using these agents in patients with bipolar disorders.
CNS stimulants (Includes armodafinil) ↔ psychotic disorders
Moderate Potential Hazard, Moderate plausibility. Applies to: Psychosis
Central nervous system (CNS) stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with a preexisting psychotic disorder. Close monitoring is recommended when using these agents in patients with psychotic disorders.
Armodafinil drug interactions
There are 397 drug interactions with armodafinil
Armodafinil alcohol/food interactions
There is 1 alcohol/food interaction with armodafinil
More about armodafinil
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- Drug class: CNS stimulants
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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