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Albenza (albendazole) Disease Interactions

There are 4 disease interactions with Albenza (albendazole):

Major

Albendazole (Includes Albenza) ↔ Myelosuppression

Severe Potential Hazard, Moderate plausibility

Applies to: Bone Marrow Depression/Low Blood Counts

Reversible leukopenia has been reported during albendazole therapy. Rarely, granulocytopenia or pancytopenia have resulted in death. Therapy with albendazole should be administered cautiously in patients with predisposition to myelosuppression. Clinical monitoring of hematopoietic function prior to each cycle of albendazole and every two weeks during therapy is recommended. Albendazole can be continued with a modest, non- progressive decrease in leukocyte count and absolute neutrophil count.

References

  1. "Product Information. Albenza (albendazole)." SmithKline Beecham, Philadelphia, PA.
  2. Fernandez FJ, Rodriguezvidigal FF, Ledesma V, Cabanillas Y, Vagace JM "Aplastic anemia during treatment with albendazole." Am J Hematol 53 (1996): 53-4
Moderate

Albendazole (Includes Albenza) ↔ Hepatobiliary Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease, Biliary Obstruction

Albendazole is converted to its biologically active metabolite and further metabolized to an inactive form by the liver. Biliary excretion of albendazole is the primary route of elimination and biliary obstruction results in increased albendazole serum concentration and AUC. Metabolism and therapeutic activity may be altered in patients with hepatic impairment. Elevated liver transaminase levels have been reported in 16% of patients receiving albendazole. Therapy with albendazole should be administered cautiously in patients with compromised hepatic function. Clinical monitoring of hepatic function is recommended prior to initiation of each cycle of albendazole and at least every two weeks during therapy. Patients with elevated liver enzyme test results are at increased risk for hepatotoxicity and bone marrow suppression. Discontinue therapy if liver enzymes are significantly increased or if a clinically significant decrease in blood cell counts occur.

References

  1. Marriner SE, Morris DL, Dickson B, Bogan JA "Pharmacokinetics of albendazole in man." Eur J Clin Pharmacol 30 (1986): 705-8
  2. Choudhuri G, Prasad RN "Jaundice due to albendazole." Indian J Gastroenterol 7 (1988): 245-6
  3. "Product Information. Albenza (albendazole)." SmithKline Beecham, Philadelphia, PA.
Moderate

Albendazole (Includes Albenza) ↔ Neurologic Dysfunction

Moderate Potential Hazard, High plausibility

Applies to: Intracranial Hypertension, Seizures

Albendazole therapy of neurocysticercosis can induce an inflammatory response within the CNS that precipitates seizures and cerebral hypertension. Therapy with albendazole for neurocysticercosis should be administered cautiously in patients with or predisposition to seizures. The use of corticosteroids during the first week of therapy to prevent cerebral hypertension and anticonvulsant therapy as required is recommended.

References

  1. "Product Information. Albenza (albendazole)." SmithKline Beecham, Philadelphia, PA.
  2. Cruz I, Cruz ME, Carrasco F, Horton J "Neurocysticercosis: optimal dose treatment with albendazole." J Neurol Sci 133 (1995): 152-4
Moderate

Albendazole (Includes Albenza) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

The pharmacokinetics of albendazole in patients with impaired renal function have not been studied. Caution is advised if used in these patients.

Albenza (albendazole) drug Interactions

There are 97 drug interactions with Albenza (albendazole)

Albenza (albendazole) alcohol/food Interactions

There is 1 alcohol/food interaction with Albenza (albendazole)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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