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NAC (acetylcysteine) Disease Interactions

There are 2 disease interactions with NAC (acetylcysteine):


Acetylcysteine (Includes NAC) ↔ hepatic encephalopathy

Severe Potential Hazard, High plausibility. Applies to: Hepatic Coma

The use of acetylcysteine should be discontinued in patients with encephalopathy due to hepatic failure to avoid further administration of nitrogenous substances.


  1. "Product Information. Mucomyst (acetylcysteine)." Apothecon Inc, Princeton, NJ.

Acetylcysteine (Includes NAC) ↔ gastric hemorrhage

Moderate Potential Hazard, Moderate plausibility. Applies to: Gastrointestinal Hemorrhage, Peptic Ulcer

The use of acetylcysteine may worsen vomiting. Patients with peptic ulcer disease should be evaluated for the risk of gastrointestinal hemorrhage. In the presence of gastric hemorrhage, the decision to administer this agent should take into consideration the benefits versus the risks to an individual patient.

NAC (acetylcysteine) drug interactions

There are 6 drug interactions with NAC (acetylcysteine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.