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NAC (acetylcysteine) Disease Interactions

There are 4 disease interactions with NAC (acetylcysteine):


Acetylcysteine (applies to NAC) hepatic encephalopathy

Major Potential Hazard, High plausibility. Applicable conditions: Hepatic Coma

The use of acetylcysteine should be discontinued in patients with encephalopathy due to hepatic failure to avoid further administration of nitrogenous substances.


  1. "Product Information. Mucomyst (acetylcysteine)." Apothecon Inc, Princeton, NJ.

Acetylcysteine (applies to NAC) asthma

Moderate Potential Hazard, Moderate plausibility.

Acetylcysteine should be used with caution in patients with asthma, or where there is a history of bronchospasm. Patients with asthma should be closely monitored during the initiation of and throughout acetylcysteine therapy.


Acetylcysteine (applies to NAC) fluid overload

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Fluid Retention

Intravenous administration of acetylcysteine can cause fluid overload, potentially resulting in hyponatremia, seizure and death. To avoid fluid overload, a diluted dose is recommended, especially in patients less than 40 kg and those requiring fluid restrictions (see dosage and administration recommended by manufacturers).


Acetylcysteine (applies to NAC) gastric hemorrhage

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage, Peptic Ulcer

The use of acetylcysteine may worsen vomiting. Patients with peptic ulcer disease should be evaluated for the risk of gastrointestinal hemorrhage. In the presence of gastric hemorrhage, the decision to administer this agent should take into consideration the benefits versus the risks to an individual patient.

NAC (acetylcysteine) drug interactions

There are 3 drug interactions with NAC (acetylcysteine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.