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Generic name: doravirine, lamivudine, and tenofovir disoproxil fumarateDOR-a-VIR-een, la-MIV-ue-deen, and-ten-OF-oh-vir ]
Drug class: Antiviral combinations

Medically reviewed by Carmen Pope, BPharm. Last updated on May 31, 2023.

What is Delstrigo?

Delstrigo contains a combination of doravirine, lamivudine and tenofovir disoproxil fumarate. Doravirine, lamivudine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus - 1 (HIV-1), the virus that causes acquired immunodeficiency syndrome (AIDS), from multiplying in your body.

Delstrigo may be used to treat HIV-1 infection in adults and pediatric patients weighing at least 35 kg:

Delstrigo is not a cure for HIV or AIDS.


Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with Delstrigo, and some drugs should not be used together.

If you've ever had hepatitis B, it may become active or get worse after you stop using this medicine. You may need frequent liver function tests for several months.

Before taking this medicine

You should not use Delstrigo if you are allergic to doravirine, lamivudine, or tenofovir.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with Delstrigo. Your doctor may change your treatment plan if you have used any of the following medicines in the past 4 weeks:

To make sure Delstrigo is safe for you, tell your doctor if you have ever had:

You may be more likely to have a broken bone while using Delstrigo. Talk with your doctor about ways to keep your bones healthy.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Delstrigo is not approved for use by anyone who weighs less than 35kg (77 pounds).

How should I take Delstrigo?

Take Delstrigo exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Take the medicine at the same time each day, with or without food.

If you also take a medicine called rifabutin, you may need to take an extra dose of doravirine (Pifeltro) about 12 hours after you take Delstrigo. Follow your doctor's dosing instructions very carefully.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Your doctor may perform blood and urine tests to make sure you do not have conditions that would prevent you from safely using this medicine. You may also need bone mineral density testing.

Store Delstrigo tablets at room temperature, away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.

Do not put the tablets into a daily pill box.

If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using this medicine. You may need frequent liver function tests while using this medicine and for several months after your last dose.

Dosing information

Usual Adult and Pediatric (over 35 kg) Dosage for HIV-1 Infection:

1 tablet orally once a day

Use: As a complete regimen, for the treatment of HIV-1 infection in patients with no prior antiretroviral treatment history or who met certain criteria for changing from another antiretroviral regimen.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely. Skipping doses may increase the risk of your virus becoming resistant to medication.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Delstrigo side effects

Get emergency medical help if you have signs of an allergic reaction to Delstrigo: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Doravirine, lamivudine, and tenofovir affect your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

Common Delstrigo side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Delstrigo?

Delstrigo can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with doravirine, lamivudine, and tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Delstrigo only for the indication prescribed.
  • Ingredients

    Active ingredients: doravirine (100mg), lamivudine (300mg), and TDF (300mg equivalent to 245 mg of tenofovir disoproxil).

    Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose acetate succinate, magnesium stearate, microcrystalline cellulose, and sodium stearyl fumarate. The film coating contains hypromellose, iron oxide yellow, lactose monohydrate, titanium dioxide, and triacetin. The coated tablets are polished with carnauba wax.


    Merck Sharp & Dohme LLC.

    Frequently asked questions


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