Generic Name: pegfilgrastim-bmez (Subcutaneous route)
peg-fil-GRA-stim - bmez
Medically reviewed by Drugs.com. Last updated on Nov 9, 2019.
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Hematopoietic
Pharmacologic Class: Pegfilgrastim
Uses for ZIEXTENZO
Pegfilgrastim-bmez injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Pegfilgrastim-bmez helps the bone marrow to make new white blood cells.
When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Pegfilgrastim-bmez is used to reduce the risk of infection while you are being treated with cancer medicines.
This medicine is available only with your doctor's prescription.
Before using ZIEXTENZO
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pegfilgrastim-bmez injection in the pediatric population.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pegfilgrastim-bmez in the elderly.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Other medical problems
- Bone marrow cancer or other bone marrow problems or
- Glomerulonephritis (kidney disease) or
- Leukocytosis (high white blood cell count) or
- Lung disease or breathing problems or
- Sickle cell disease (red blood cell disease)—Use with caution. May make these conditions worse.
Proper use of ZIEXTENZO
A nurse or other trained health professional may give you this medicine. It is given as a shot under the skin of your upper arm, upper outer buttock, stomach, or thigh.
You may be taught how to give this medicine at home. Make sure you understand all of the instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
This medicine comes with a patient information leaflet and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions about:
- How to prepare the injection.
- The proper use of disposable syringes.
- How to give the injection.
- How long the injection can be stored at home.
Allow the medicine to warm to room temperature for 15 to 30 minutes before you inject it. If the medicine in the prefilled syringe has changed color, looks cloudy, or if you see particles in it, do not use it. Do not shake.
Use the syringe only once. Do not save leftover medicine.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
- For injectable dosage form (solution):
- To increase white blood cell count:
- Adults—6 milligrams (mg) as a single injection under the skin once every cancer treatment cycle.
- Children weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
- Weighing 31 kg to 44 kg—4 milligrams (mg) as a single injection under the skin once every cancer treatment cycle.
- Weighing 21 kg to 30 kg—2.5 mg as a single injection under the skin once every cancer treatment cycle.
- Weighing 10 kg to 20 kg—1.5 mg as a single injection under the skin once every cancer treatment cycle.
- Weighing less than 10 kg—0.1 mg per kg body weight as a single injection under the skin once every cancer treatment cycle.
- To increase white blood cell count:
This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Store in the refrigerator. Do not freeze.
Keep this medicine in its original carton. Throw away any medicine stored at room temperature for more than 72 hours. If frozen, thaw it in the refrigerator before using. Throw away any medicine if it has been frozen more than once.
Throw away used needles in a hard, closed container where the needles cannot poke through. Keep this container away from children and pets.
Precautions while using ZIEXTENZO
It is very important that your doctor check you or your child's progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
If you or your child have left upper stomach pain or shoulder pain, contact your doctor right away. This could be a symptom of a serious side effect with the spleen.
Check with your doctor right away at the first sign of any infection, such as fever, chills, cough, sore throat, or redness, swelling, or pain around a cut or sore.
Check with your doctor right away if you or your child develop a fever, chest pain or tightness, fast breathing, or trouble breathing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS).
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash, itching, swelling of the face, tongue, or throat, trouble breathing, or chest pain after you receive the medicine.
You should not use this medicine for 14 days before and up to 24 hours after you receive cancer medicines.
This medicine may cause kidney problems. Call your doctor right away if you or your child has swelling in the face or ankles, blood in the urine, or a decrease in how much or how often you urinate.
Check with your doctor right away if you or your child has black or tarry stools, bleeding gums, blood in the urine or stools, pinpoint red spots on the skin, or unusual bleeding or bruising after receiving this medicine.
This medicine may cause a condition called capillary leak syndrome. It can cause fluid to leak from the blood vessels into your body's tissues. Call your doctor right away if you have swelling or puffiness and are urinating less often, trouble breathing, feeling of fullness, dizziness, or feeling faint.
This medicine may cause aortitis (inflammation of the aorta, the largest artery in the body). Check with your doctor right away if you have fever, stomach pain, unusual tiredness or weakness, or back pain.
Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests (eg, bone tests).
The needle cover of the pre-filled syringe contains dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you have a latex allergy before you start using this medicine.
ZIEXTENZO side effects
Check with your doctor immediately if any of the following side effects occur:
Incidence not known
- Abdominal or stomach pain
- bloody or cloudy urine
- blue lips, fingernails, or skin
- cloudy urine
- decrease or increase in the amount of urine
- difficult or fast breathing
- difficulty swallowing
- eye pain
- fainting or lightheadedness
- fast heartbeat
- general feeling of illness
- hives, itching, or skin rash
- pain spreading to the left shoulder
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- sore throat
- stomach pain
- swelling of the face, feet, or lower legs
- swelling of the hands, ankles, feet, or lower legs
- tightness in the chest
- unusual tiredness or weakness
- weight gain
Incidence not known
- Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- bone, arm, or leg pain
Copyright 2020 Truven Health Analytics, Inc. All Rights Reserved.
- What is the difference between Fulphila and Neulasta?
- What is the difference between Udenyca and Neulasta?
- How many biosimilars have been approved in the United States?
More about Ziextenzo (pegfilgrastim)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: colony stimulating factors
- FDA Approval History