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Some commonly used brand names are:

In the U.S.—

  • Depo-Testadiol 2
  • Estratest 1
  • Estratest H.S. 1
  • Valertest No. 1 2

In Canada—

  • Climacteron 2


For quick reference, the following androgens and estrogens are numbered to match the corresponding brand names.

This information applies to the following medicines:
1. Estrogens, Esterified, and Methyltestosterone (ESS-troe-jenz, ess-TAIR-i-fyed, and meth-il-tes-TOSS-ter-one)
2. Testosterone and Estradiol (tess-TOSS-ter-own and ess-tra-DYE-ole)
‡ Generic name product may be available in the U.S.


  • Androgen-estrogen
  • This monograph includes information on the following: —Estrogens, Esterified, and Methyltestosterone; Testosterone and Estradiol


Androgens and estrogens (AN-droe-jens and ESS-troe-jens) are hormones. Estrogens are produced by the body in greater amounts in females. They are necessary for normal sexual development of the female and for regulation of the menstrual cycle during the childbearing years. Androgens are produced by the body in greater amounts in males. However, androgens are also present in females in small amounts.

The ovaries and adrenal glands begin to produce less of these hormones after menopause. This combination product is prescribed to make up for this lower production of hormones. This may relieve signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness.

Androgens and estrogens may also be used for other conditions as determined by your doctor.

There is no medical evidence to support the belief that the use of estrogens (contained in this combination medicine) will keep the patient feeling young, keep the skin soft, or delay the appearance of wrinkles. Nor has it been proven that the use of estrogens during the menopause will relieve emotional and nervous symptoms, unless these symptoms are caused by other menopausal symptoms, such as hot flashes.

A paper called “Information for the Patient” should be given to you with your prescription. Read this carefully . Also, before you use an androgen and estrogen product, you and your doctor should discuss the good that it will do as well as the risks of using it.

This medicine is available only with your doctor's prescription, in the following dosage forms:

  • Oral
  • Estrogens, Esterified, and Methyltestosterone
    • Tablets (U.S.)
  • Parenteral
  • Testosterone and Estradiol
    • Injection (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For androgen and estrogen combination products, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to androgens, anabolic steroids, or estrogens. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Estrogens (contained in this combination medicine) are not recommended for use during pregnancy, since some estrogens have been shown to cause serious birth defects in humans. Some daughters of women who took diethylstilbestrol (DES) during pregnancy have developed reproductive (genital) tract problems and, rarely, cancer of the vagina and/or uterine cervix when they reached childbearing age. Some sons of women who took DES during pregnancy have developed urinary-genital tract problems.

Androgens (contained in this combination medicine) should not be used during pregnancy because they may cause male-like changes in a female baby.

Breast-feeding—Use of this medicine is not recommended in nursing mothers. Estrogens pass into the breast milk and their possible effect on the baby is not known. It is not known if androgens pass into breast milk. However, androgens may cause unwanted effects in nursing babies such as too early sexual development in males or male-like changes in females.

Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older women than it does in younger females.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking an androgen and estrogen combination product, it is especially important that your health care professional know if you are taking any of the following:

  • Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or
  • Amiodarone (e.g., Cordarone) or
  • Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g., Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
  • Anti-infectives by mouth or by injection (medicine for infection) or
  • Antithyroid agents (medicine for overactive thyroid) or
  • Carbamazepine (e.g., Tegretol) or
  • Carmustine (e.g., BiCNU) or
  • Chloroquine (e.g., Aralen) or
  • Dantrolene (e.g., Dantrium) or
  • Daunorubicin (e.g., Cerubidine) or
  • Disulfiram (e.g., Antabuse) or
  • Divalproex (e.g., Depakote) or
  • Etretinate (e.g., Tegison) or
  • Gold salts (medicine for arthritis) or
  • Hydroxychloroquine (e.g., Plaquenil) or
  • Mercaptopurine (e.g., Purinethol) or
  • Methotrexate (e.g., Mexate) or
  • Methyldopa (e.g., Aldomet) or
  • Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
  • Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril]) or
  • Phenytoin (e.g., Dilantin) or
  • Plicamycin (e.g., Mithracin) or
  • Valproic acid (e.g., Depakene)—Androgens, estrogens, and all of these medicines can cause liver damage. Your doctor may want you to have extra blood tests that tell about your liver, while you are taking any of these medicines with an androgen and estrogen combination product.
  • Anticoagulants (blood thinners)—Androgens can cause an increased effect of blood thinners, which could lead to uncontrolled or excessive bleeding
  • Cyclosporine (e.g., Sandimmune)—Estrogens can increase the chances of toxic effects to the kidney or liver from cyclosporine because estrogens can interfere with the body's ability to get the cyclosporine out of the bloodstream as it normally would

Other medical problems—The presence of other medical problems may affect the use of androgen and estrogen combination products. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots (or history of during previous estrogen therapy)—Estrogens may worsen blood clots or cause new clots to form
  • Breast cancer (active or suspected)—Estrogens may cause growth of the tumor
  • Changes in vaginal bleeding of unknown causes—Some irregular vaginal bleeding is a sign that the lining of the uterus is growing too much or is a sign of cancer of the uterus lining; estrogens may make these conditions worse
  • Type 2 diabetes mellitus—Androgens can decrease blood sugar levels
  • Edema (swelling of feet or lower legs caused by retaining [keeping] too much body water) or
  • Heart or circulation disease or
  • Kidney disease or
  • Liver disease—Androgens can worsen these conditions because androgens cause the body to retain extra fluid (keep too much body water). Also, heart or circulation disease can be worsened by androgens because androgens may increase blood cholesterol levels
  • Endometriosis—Estrogens may worsen endometriosis by causing growth of endometriosis implants
  • Fibroid tumors of the uterus—Estrogens may cause fibroid tumors to increase in size
  • Gallbladder disease or gallstones (or history of)—There is no clear evidence as to whether estrogens increase the risk of gallbladder disease or gallstones
  • Jaundice (or history of during pregnancy)—Estrogens use may worsen or cause jaundice in these patients
  • Liver disease—Toxic drug effects may occur in patients with liver disease because the body is not able to get this medicine out of the bloodstream as it normally would
  • Porphyria—Estrogens can worsen porphyria

Proper Use of This Medicine

For patients taking any of the androgen and estrogen products by mouth:

  • Take this medicine only as directed by your doctor. Do not take more of it and do not take it for a longer time than your doctor ordered .
  • Try to take the medicine at the same time each day to reduce the possibility of side effects and to allow it to work better.
  • Nausea may occur during the first few weeks after you start taking estrogens. This effect usually disappears with continued use. If the nausea is bothersome, it can usually be prevented or reduced by taking each dose with food or immediately after food.

Dosing—The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking combinations of androgen and estrogen .

  • For esterified estrogens and methyltestosterone
  • For oral dosage form (tablets):
    • For treatment of certain signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness:
      • Adults—0.625 to 2.5 mg of esterified estrogens and 1.25 to 5 mg of methyltestosterone once a day for twenty-one days. Stop the medicine for seven days, then repeat the twenty-one day cycle.
  • For testosterone cypionate and estradiol cypionate
  • For injection dosage form:
    • For treatment of certain signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness:
      • Adults—50 milligrams (mg) of testosterone cypionate and 2 mg of estradiol cypionate injected into a muscle once every four weeks.
  • For testosterone enanthate and estradiol valerate
  • For injection dosage form:
    • For treatment of certain signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness:
      • Adults—90 milligrams (mg) of testosterone enanthate and 4 mg of estradiol valerate injected into a muscle once every four weeks.
  • For testosterone enanthate benzilic acid hydrazone, estradiol dienanthate, and estradiol benzoate
  • For injection dosage form:
    • For treatment of bone loss (osteoporosis) or certain signs of menopause, such as hot flashes and unusual sweating, chills, faintness, or dizziness:
      • Adults—150 milligrams (mg) of testosterone enanthate benzilic acid hydrazone, 7.5 mg of estradiol dienanthate, and 1 mg of estradiol benzoate injected into a muscle once every four to eight weeks or less.

Missed dose—If you miss a dose of this medicine and your dosing schedule is:

  • One dose a day—Take the missed dose as soon as possible. However, if you do not remember it until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
  • More than one dose a day—Take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you have any questions about this, check with your doctor.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store in the bathroom medicine cabinet because the heat or moisture may cause the medicine to break down.
  • Keep the injectable form of this medicine from freezing.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is very important that your doctor check your progress at regular visits to make sure this medicine does not cause unwanted effects . These visits will usually be every 6 to 12 months, but many doctors require them more often.

It is not yet known whether the use of estrogen increases the risk of breast cancer in women. Therefore, it is very important that you regularly check your breasts for any unusual lumps or discharge. You should also have a mammogram (x-ray picture of the breasts) done if your doctor recommends it.

In some patients using estrogens, tenderness, swelling, or bleeding of the gums may occur. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your medical doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums.

For diabetic patients:

  • This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

If you think that you may have become pregnant, check with your doctor immediately . Continued use of this medicine during pregnancy may cause birth defects or future health problems in the child.

In studies with oral contraceptives (birth control pills) containing estrogens, cigarette smoking during the use of estrogens was shown to cause an increased risk of serious side effects affecting the heart or blood circulation, such as dangerous blood clots, heart attack, or stroke. The risk increased as the amount of smoking and the age of the smoker increased. Women aged 35 and over were at greatest risk when they smoked while using oral contraceptives containing estrogens. It is not known if this risk exists with the use of androgens and estrogens for symptoms of menopause. However, smoking may make estrogens less effective.

Do not give this medicine to anyone else. Your doctor has prescribed it specifically for you after studying your health record and the results of your physical examination. Androgens and estrogens may be dangerous for some people because of differences in their health and body chemistry.

Side Effects of This Medicine

Discuss these possible effects with your doctor:

  • Tumors of the liver, liver cancer, and peliosis hepatis (a form of liver disease) have occurred during long-term, high-dose therapy with androgens. Although these effects are rare, they can be very serious and may cause death.
  • When androgens are used in women, especially in high doses, male-like changes may occur, such as hoarseness or deepening of the voice, unnatural hair growth, or unusual hair loss. Most of these changes will go away if the medicine is stopped as soon as the changes are noticed. However, some changes, such as voice changes, may not go away.
  • The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the uterus lining) in women after menopause. The risk seems to increase as the dose and the length of use increase. When estrogens are used in low doses for less than one year, there is less risk. The risk is also reduced if a progestin (another female hormone) is added to, or replaces part of, your estrogen dose. If the uterus has been removed by surgery (total hysterectomy), there is no risk of endometrial cancer.
  • It is not yet known whether the use of estrogens increases the risk of breast cancer in women. Although some large studies show an increased risk, most studies and information gathered to date do not support this idea.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Yellow eyes or skin


Uncontrolled jerky muscle movements; vomiting of blood (with long-term use or high doses)

Also, check with your doctor as soon as possible if any of the following side effects occur:

More common

Acne or oily skin (severe); breast pain or tenderness; changes in vaginal bleeding (spotting, breakthrough bleeding, prolonged or heavier bleeding, or complete stoppage of bleeding); enlarged clitoris; enlargement or decrease in size of breasts; hoarseness or deepening of voice; swelling of feet or lower legs; unnatural hair growth; unusual hair loss; weight gain (rapid)

Less common or rare

Confusion; dizziness; flushing or redness of skin; headaches (frequent or continuing); hives (especially at place of injection); shortness of breath (unexplained); skin rash, hives, or itching; unusual bleeding; unusual tiredness or drowsiness

With long-term use or high doses

Black, tarry, or light-colored stools; dark-colored urine; general feeling of discomfort or illness (continuing); hives (frequent or continuing); loss of appetite (continuing); lump in, or discharge from breast; nausea (severe); pain, swelling, or tenderness in stomach or upper abdomen (continuing); purple- or red-colored spots on body or inside the mouth or nose; sore throat or fever (continuing); unpleasant breath odor (continuing); vomiting (severe)

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Bloating of abdomen or stomach; cramps of abdomen or stomach; loss of appetite (temporary); nausea (mild); stomach pain (mild); unusual increase in sexual desire; vomiting (mild)

Less common

Constipation; diarrhea (mild); dizziness (mild); headaches (mild); infection, redness, pain, or other irritation at place of injection; migraine headaches; problems in wearing contact lenses; trouble in sleeping

Also, many women who are taking a progestin (another type of female hormone) with this medicine will begin to have monthly vaginal bleeding again, similar to menstrual periods. This effect will continue for as long as this medicine is used. However, monthly bleeding will not occur in women who have had the uterus removed by surgery (total hysterectomy).

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 01/14/2003

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.