Skip to Content
How to talk to a doctor about advanced ovarian cancer >>

siltuximab (Intravenous route)


Commonly used brand name(s)

In the U.S.

  • Sylvant

Available Dosage Forms:

  • Powder for Solution

Pharmacologic Class: Monoclonal Antibody

Uses For siltuximab

Siltuximab injection is used to treat a rare blood disorder called multicentric Castleman's disease (MCD). siltuximab is used in patients who do not have human immunodeficiency virus (HIV) and human herpes virus-8 (HHV-8) infection.

siltuximab is to be given only by or under the direct supervision of your doctor.

Before Using siltuximab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For siltuximab, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to siltuximab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of siltuximab injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of siltuximab injection in the elderly.


Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving siltuximab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using siltuximab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone
  • Adenovirus Vaccine Type 4, Live
  • Adenovirus Vaccine Type 7, Live
  • Ado-Trastuzumab Emtansine
  • Alfentanil
  • Alprazolam
  • Aminophylline
  • Amiodarone
  • Amlodipine
  • Amprenavir
  • Apixaban
  • Aprepitant
  • Aripiprazole
  • Artemether
  • Astemizole
  • Atazanavir
  • Atorvastatin
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Bedaquiline
  • Boceprevir
  • Bosutinib
  • Brentuximab Vedotin
  • Brinzolamide
  • Bromocriptine
  • Budesonide
  • Buprenorphine
  • Buspirone
  • Cabazitaxel
  • Cabozantinib
  • Carbamazepine
  • Cilostazol
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clonazepam
  • Clozapine
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclophosphamide
  • Cyclosporine
  • Dabrafenib
  • Darifenacin
  • Darunavir
  • Dasatinib
  • Delavirdine
  • Dexamethasone
  • Dihydroergotamine
  • Diltiazem
  • Docetaxel
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Dutasteride
  • Eletriptan
  • Elvitegravir
  • Enzalutamide
  • Eplerenone
  • Ergotamine
  • Erythromycin
  • Eslicarbazepine Acetate
  • Estradiol
  • Ethinyl Estradiol
  • Everolimus
  • Felodipine
  • Fentanyl
  • Fluticasone
  • Fosamprenavir
  • Fosaprepitant
  • Haloperidol
  • Hydrocodone
  • Iloperidone
  • Imatinib
  • Indinavir
  • Influenza Virus Vaccine, Live
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ketoconazole
  • Lapatinib
  • Letrozole
  • Levomilnacipran
  • Levonorgestrel
  • Lomitapide
  • Lopinavir
  • Losartan
  • Lovastatin
  • Lumefantrine
  • Lurasidone
  • Macitentan
  • Maraviroc
  • Measles Virus Vaccine, Live
  • Medroxyprogesterone
  • Mefloquine
  • Methadone
  • Midazolam
  • Mifepristone
  • Mumps Virus Vaccine, Live
  • Nateglinide
  • Nelfinavir
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nisoldipine
  • Ondansetron
  • Ospemifene
  • Oxycodone
  • Paclitaxel
  • Pazopanib
  • Perampanel
  • Phenytoin
  • Pimozide
  • Piperaquine
  • Poliovirus Vaccine, Live
  • Pomalidomide
  • Ponatinib
  • Prednisolone
  • Prednisone
  • Propafenone
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Regorafenib
  • Rifabutin
  • Rilpivirine
  • Ritonavir
  • Roflumilast
  • Rotavirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Sildenafil
  • Simeprevir
  • Simvastatin
  • Sirolimus
  • Smallpox Vaccine
  • Solifenacin
  • Sorafenib
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Tamsulosin
  • Telaprevir
  • Telithromycin
  • Temsirolimus
  • Terfenadine
  • Theophylline
  • Ticagrelor
  • Tipranavir
  • Tolvaptan
  • Toremifene
  • Trabectedin
  • Tramadol
  • Trazodone
  • Triamcinolone
  • Triazolam
  • Typhoid Vaccine
  • Vandetanib
  • Vardenafil
  • Varicella Virus Vaccine
  • Vemurafenib
  • Verapamil
  • Vilanterol
  • Vilazodone
  • Vincristine
  • Vinflunine
  • Voriconazole
  • Warfarin
  • Yellow Fever Vaccine
  • Zaleplon
  • Zileuton
  • Ziprasidone
  • Zolpidem

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of siltuximab. Make sure you tell your doctor if you have any other medical problems, especially:

  • Stomach or bowel problems (eg, diverticulitis, ulcers)—Use with caution. May increase risk for gastrointestinal perforation.
  • Infection, severe—May decrease your body's ability to fight infection. It must be treated first before using siltuximab.

Proper Use of siltuximab

A nurse or other trained health professional will give you siltuximab in a hospital. siltuximab is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 1 hour.

siltuximab comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Precautions While Using siltuximab

If you will be using siltuximab for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by siltuximab. Blood tests may be needed to check for unwanted effects.

Make sure your doctor knows if you are pregnant or planning to become pregnant. You must use an effective form of birth control to keep from getting pregnant during therapy and for 3 months after the last dose of siltuximab.

Your body's ability to fight infection may be reduced while you are using siltuximab. It is very important that you call your doctor at the first sign of any infection. Check with your doctor right away if you have any of the following symptoms while receiving siltuximab: a fever, chills, cough, flu-like symptoms, or unusual tiredness or weakness.

While you are being treated with siltuximab, do not have any immunizations (vaccines) without your doctor's approval. Live virus vaccines should not be given with siltuximab or soon after you receive it.

siltuximab may cause a serious allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving siltuximab.

Siltuximab may cause an infusion reaction while you are receiving it or right after the infusion ends. Check with your doctor or nurse right away if you have back pain, chest pain or discomfort, fast or uneven heartbeat, nausea or vomiting, trouble breathing, or redness of the face, neck, arms, and upper chest.

siltuximab may increase your risk of gastrointestinal perforation. Tell your doctor right away if you have any of the following symptoms: severe abdominal or stomach pain or cramps, bloody, black, or tarry stools, or vomiting of material that looks like coffee grounds.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

siltuximab Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody urine
  • blurred vision
  • body aches or pain
  • chills
  • confusion
  • cough
  • decreased frequency or amount of urine
  • difficulty with breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • fever
  • full or bloated feeling
  • headache
  • increased thirst
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • nausea
  • pinpoint red spots on the skin
  • pressure in the stomach
  • rapid weight gain
  • runny nose
  • sneezing
  • sore throat
  • sweating
  • swelling of the abdominal or stomach area
  • tingling of the hands or feet
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
Less common
  • Back pain
  • chest pain or discomfort
  • dizziness
  • dry mouth
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • flushing or redness of the skin
  • lightheadedness
  • rapid breathing
  • redness of the face, neck, arms, and occasionally, upper chest
  • sunken eyes
  • unusually warm skin
  • wrinkled skin
  • Difficulty with swallowing
  • hives, itching, or skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • difficulty with moving
  • joint pain, stiffness, or swelling
  • muscle pain or stiffness
  • rash with flat lesions or small raised lesions on the skin
Less common
  • Darkening of the skin
  • decreased appetite
  • dry skin
  • skin rash, encrusted, scaly, and oozing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

The information contained in the Truven Health Micromedex products as delivered by is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.

Copyright 2016 Truven Health Analytics, Inc. All Rights Reserved.